. The thyroid gland in health and disease. the goitre of Graves Disease and simple goitre. Sinceperiods of rest are necessary for the glands recuperation, ultimateexhaustion of the cells occurs when these are not provided. Inthis case degenerative changes occur in the secreting cells (). They become vacuolated, irregular in shape and size,desquamation increases and desquamated cells and cell-debrisfill the vesicles (fig. 23). The nuclei become more irregular inshape and size, and cell-regeneration cannot keep pace with cell-destruction. Fibroblasts take the place of the dead parenchymace
. The thyroid gland in health and disease. the goitre of Graves Disease and simple goitre. Sinceperiods of rest are necessary for the glands recuperation, ultimateexhaustion of the cells occurs when these are not provided. Inthis case degenerative changes occur in the secreting cells (). They become vacuolated, irregular in shape and size,desquamation increases and desquamated cells and cell-debrisfill the vesicles (fig. 23). The nuclei become more irregular inshape and size, and cell-regeneration cannot keep pace with cell-destruction. Fibroblasts take the place of the dead parenchymacells, and the fibrous stroma of the organ becomes greatly in-creased (fig. 24). The glands powers of compensation and cell-regeneration have failed, its reserve force is exhausted. Thisprocess results in myxcedema, which may follow any prolongedtoxic excitation of the thyroid ; it is a natural sequel of such 72 PATHOLOGY excitation in all cases of Graves Disease that do not recoverspontaneously, or in which death does not supervene. In all. Fig. 21.—Section of thyroid from a case of Graves Disease. Note heightenedand heaped-up epithelium, irregular-shaped vesicles empty of stainable colloid,containing cellular debris ; increase of fibrous stroma; also lymphocytic a specimen in the possession of the late Sir Victor Horsley,
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Keywords: ., bookcentury1900, bookdecade1910, bookpublishernewyorkwilliamwood
