Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . t is a matter of some interest that, in cats atleast, the vaso-motor centre is more sensitive tolow blood pressure than to want of oxygen in theblood. In Fig. 51 we see that the vaso-motorreflex is not abolished when the blood pressure hasalready fallen very low and the respiration hasceased. The first three-quarters of an hour ofdeficient oxygen had no effect on the vaso-motorreflex, not much on the respiratory centre, but apermanent effect was left
Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . t is a matter of some interest that, in cats atleast, the vaso-motor centre is more sensitive tolow blood pressure than to want of oxygen in theblood. In Fig. 51 we see that the vaso-motorreflex is not abolished when the blood pressure hasalready fallen very low and the respiration hasceased. The first three-quarters of an hour ofdeficient oxygen had no effect on the vaso-motorreflex, not much on the respiratory centre, but apermanent effect was left behind, because the centreswere more easily affected by later applications ofthe same deficient supply, even after an hoursinterval with not so great a deficiency. The delayedeffects of asphyxial conditions due to want of oxygenhave an importance in connection with the effectsof pulmonary irritant gases and with the possibilityof cumulative action in the case of the are, indeed, being made on theselines. The rebreathing of expired air has been recom-mended by Townshend Porter and by Yandell9 130 INTRAVENOUS INJECTION. Fir,. 51. —Effect on the Vasomotor Centre of Breathing AirDeficient in Oxygen. First stimulation, of central end of sciatic nerve, ten minutes aftercommencement of rebreathing expired air with the carbon dioxide absorbedby sodium hydroxide close to the tracheal canula. After the fourth stimulation, forty minutes after commencement, moreoxygen was admitted by the use of a shorter tube, since the respiration beganto fail. The long tube was replaced after an hour, but breathing soonstopped, so that it had to be removed. It was replaced again ten minuteslater, and six minutes afterwards stimulation 7 was obtained. No. 8 wastwo minutes later, and No. 9 two minutes later still, just after respiration hadstopped. Normal air was then admitted, with recovery. IN WOUND SHOCK 131 Henderson as a treatment for wound shock, althoughon different grounds.
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