The diseases of infants and children . t is great, in that it enables usto determine what subjects are already immune. Those who give anegative reaction do not need antitoxin injections. This is a matter ofmoment from an economical point of view when considerable numbers ofpatients are to be immunized, and is important, too, when an anaphy-lactic reaction is feared in those who have previously received about 40 to 50 per cent, of children from 1 to 15 years are naturallyimmune (Kolmer and Moshage), it is evident that artificial immuniza-tion is required in only half of the chil


The diseases of infants and children . t is great, in that it enables usto determine what subjects are already immune. Those who give anegative reaction do not need antitoxin injections. This is a matter ofmoment from an economical point of view when considerable numbers ofpatients are to be immunized, and is important, too, when an anaphy-lactic reaction is feared in those who have previously received about 40 to 50 per cent, of children from 1 to 15 years are naturallyimmune (Kolmer and Moshage), it is evident that artificial immuniza-tion is required in only half of the children who have been exposed. Inthe first 6 months of life there appears to be in most cases a naturalimmunity. 1 Niederl. Tijdsch. v. Geeneesk., 1914, 1066. 2 Arch, of Fed., 1912, XXIX, 94. 3 Mtinch. med. Woch., 1913, LX, 2608. * Journ. Amer. Med. Assoc, 1915, LXIV, Arch, of Pediat., 1914, XXXI, 481.« Amer. Jour. Dis. Child., 1915, IX, 189. 7 Trans. Amer. Pediat. Soc, 1916, XXVIII, 329. 8 Amer. Jour. Dis. Child., 1916, XI,


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