. Control of ovulation; proceedings of the conference held at Endicott House, Dedham, Massachusetts, 1960. Ovulation -- Regulation. 116 Discussions (stria temiinaiis) has occurred? With regard to the first question we have obtained some recent data which would further tend to support the hypothesis that the anterior hypothalamic area is the site of the deleterious androgen action. The biphasic action of progesterone in first facilitating and then inhibiting the discharge of gonadotropin in the rat is well recognized. Everett {Endocrinology 43, 389, 1948) has demonstrated that administration of
. Control of ovulation; proceedings of the conference held at Endicott House, Dedham, Massachusetts, 1960. Ovulation -- Regulation. 116 Discussions (stria temiinaiis) has occurred? With regard to the first question we have obtained some recent data which would further tend to support the hypothesis that the anterior hypothalamic area is the site of the deleterious androgen action. The biphasic action of progesterone in first facilitating and then inhibiting the discharge of gonadotropin in the rat is well recognized. Everett {Endocrinology 43, 389, 1948) has demonstrated that administration of progesterone to a normal cyclic. Fig. 7. Effects of spaced injections of progesterone on vaginal cycle of androgen-sterilized, persistent-estrous rat. Abbreviations used in this and Fig. 8: I, Proestrus; III, Estrus; L, Laparotomy; CL, Corpora lutea; A, Autopsy. Solid bars indicate persistent vaginal comification; blank spaces represent days of diestrus. rat on the last day of diestrus will advance ovulation one day. Spaced injections of progesterone when administered to the spontaneous persistent-estrous rat (DBN strain) will likewise induce ovulation (Everett, J. W., Endocrinology 32, 285, 1943). We have attempted also to ovulate the androgen-sterilized rat by either spaced or daily injections of progesterone. Following the procedure described by Everett (1943) for the induction of ovulation in the spontaneous persistent-estrous rat, single "inter- rupting" dosages of mg of progesterone were administered to each of 4 groups of 8 adult sterile rats. This injection generally resulted in a 3-day period of diestrus followed by one day of proestrus at which time a second "ovulatory" dose of proges- terone was administered. Laparotomy was ordinarily performed 48 hr after the second injection, at which time the ovaries were examined for the presence of corpora lutea. Regardless of the dosage used, ovulation did not occur (Fig. 7). These results were confirme
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