Archives of internal medicine . *-rc. / f / / / \ / 100. o Fig. 4 (Exp. IX).—Curves of dog with abnormally low blood-pressure. Aslight increase of intraspinal pressure caused the respiration to stop without car-diac inhibition. Atropin increased the pulse rate but failed to stimulate therespiratory center. Cushing found that when the intracranial pressure is increased untilit approximates the mean blood-pressure, there is pronounced cardiacinhibition, with very slow, shallow and often irregular respiration; thatthese effects are most pronounced when the intracranial pressure isincreased rapidl
Archives of internal medicine . *-rc. / f / / / \ / 100. o Fig. 4 (Exp. IX).—Curves of dog with abnormally low blood-pressure. Aslight increase of intraspinal pressure caused the respiration to stop without car-diac inhibition. Atropin increased the pulse rate but failed to stimulate therespiratory center. Cushing found that when the intracranial pressure is increased untilit approximates the mean blood-pressure, there is pronounced cardiacinhibition, with very slow, shallow and often irregular respiration; thatthese effects are most pronounced when the intracranial pressure isincreased rapidly and may cause complete cardiac inhibition, lasting fromten to twenty seconds; that this cardiac inhibition can be avoided by sec-tion of the vagi. 2. Cushing, IT.: Bull. Johns Hopkins Hospital, 1901, xii, 290. 430 ARCHIVES OF INTERNAL MEDICINE Cushing found that when the intracranial pressure approaches themean blood-pressure a rise of blood-pressure follows, due to stimulationof the vasomotor center in the medulla. This regulatory action of thedom
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