Archives of internal medicine . ntraspinal pressure was noted 1> and called to another who recorded it immediately under the registration of the blood-pressure on the revolv-ing drum. In some of the experiments the intraspinal pressure was recorded onthe drum by a writing style on a mercury manometer, as dishing made a tracingof the intracranial pressure. Autopsies.— Immediately after each experiment an autopsy was made to deter-mine if both needles had punctured the membranes, the location of the fluidinjected, and the extent to which it bad extended to the intracranial cavity. The brain a
Archives of internal medicine . ntraspinal pressure was noted 1> and called to another who recorded it immediately under the registration of the blood-pressure on the revolv-ing drum. In some of the experiments the intraspinal pressure was recorded onthe drum by a writing style on a mercury manometer, as dishing made a tracingof the intracranial pressure. Autopsies.— Immediately after each experiment an autopsy was made to deter-mine if both needles had punctured the membranes, the location of the fluidinjected, and the extent to which it bad extended to the intracranial cavity. The brain and cord were removed and fixed in 10 per tent, dilution of liquorformaldehydi in distilled water. The alkaline salts of tap water cause the solu-tion and diffusion of some of the carmin injected. ; OF EXPERIMENTS The first experiment was made with only one needle introduced intothe spinal subarachnoid space. The intraspinal pressure was measured 77/0 11-10 I HO U-35 HMO /IMS //SO, l)SS J200 /20SJ2I0 12 IS I21Q \3Qc~. 100 r^.J- — so £x/>.m J2 I I Fig. 7 (Exp. VIII).—Another experimenl of Group II. A slight increase ofintraspinal pressure to 10 mm. Hg caused sudden ct-ssation of respiration followedby abrupt and complete cardiac inhibition. Atropin restored the normal heartbeal within l» seconds bui spontaneous respirations only started after threeminute- of artificial respiration. Subsequent to the administration of atropin, the intraspinal injection of aamounl of Ringers solution, under a higher in essure, failed to produce cardiac inhibition, bul each injection reduced the respiratory rate blood pressure rose in these late injections a- in Experimenl 7 (Fig. 6). injections, and again after they had been compli ted; bul there• r the norma] i !?> nun. Ringers solution or 3 mm. ofmercury). [njections of 3 to \ were made ai a time, taking from two min(o thi ach injection as the injecting pressure incn :iLr v. iili an injecting pi mm. of m
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