. The cyclopædia of anatomy and physiology. Anatomy; Physiology; Zoology. Appearance of homogeneous globules of various sizes and shapes, occasionally seen in the follicle of the pancreas. From the Eat. {Magnified 200 dia- meters.') pressed by neighbouring ones. They range in size from 1J0 0 to -^^ of an inch, and are evi- dently not contained in any cell-membrane. (Seejtfg. 60.) The appearance, in my opinion, results from a spontaneous solution of the epithelium in the follicles, and a separation of the different elements of the secretion; but what are the particular circumstances that de- te
. The cyclopædia of anatomy and physiology. Anatomy; Physiology; Zoology. Appearance of homogeneous globules of various sizes and shapes, occasionally seen in the follicle of the pancreas. From the Eat. {Magnified 200 dia- meters.') pressed by neighbouring ones. They range in size from 1J0 0 to -^^ of an inch, and are evi- dently not contained in any cell-membrane. (Seejtfg. 60.) The appearance, in my opinion, results from a spontaneous solution of the epithelium in the follicles, and a separation of the different elements of the secretion; but what are the particular circumstances that de- termine it I do not know; the longer the object is kept under the microscope, the more marked is the appearance, and the larger the globules, from their running one into the other : it is possible that endosmosis may have something to do with it, for I do not remember ever to have seen the appearance in specimens promptly examined immediately after death.* y. Occasionally there is an appearance of a central cavity in each follicle, the epithelium lining it in a single columnar-looking layer, and leaving a central space unoccupied. The central space thus left is very small, not ex- ceeding in diameter that of the thickness of the epithelial layer lining the follicle; it is only now and then that this appearance can be detected, and even then it requires careful focussing to see it satisfactorily : it may either arise from the epithelium being shed in suc- cessive generations of layers,—one passing from the follicle as the succeeding crop is produced,—or it may be explained by the mere liquefaction of the central and older cells, ' which, escaping in a fluid form from the fol- licle, leave the peripheral cells with a definite * Since writing the above, I have had satisfac- tory evidence that the appearance is owing to en- dosmosis. I have seen the globules form under the microscope from their first trace to their attainment of a size equal to that shown in the figure. Some- ti
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