An American text-book of genito-urinary diseases, syphilis and diseases of the skin . ped opening,which is filled with a mass of horn-cells continuous with the thick crust orprojecting horn that covers the follicular orifice. The wall of the follicle iscomposed of an abnormally thick horny layer which limits a rete whose cellsare irregularly arranged and whose basal layers shows signs of very activeproliferation. The rete is of irregular thickness, in some places being limitedto one or two layers, in others sending numerous long digitations into thecutis—a constant and characteristic feature w


An American text-book of genito-urinary diseases, syphilis and diseases of the skin . ped opening,which is filled with a mass of horn-cells continuous with the thick crust orprojecting horn that covers the follicular orifice. The wall of the follicle iscomposed of an abnormally thick horny layer which limits a rete whose cellsare irregularly arranged and whose basal layers shows signs of very activeproliferation. The rete is of irregular thickness, in some places being limitedto one or two layers, in others sending numerous long digitations into thecutis—a constant and characteristic feature which Darier expressed in theterm vegetante. Here and there in the rete there are irregular spaces,lacunae, around which the cells have lost their prickles and their nuclei andstain feebly. In the lower portion of the mass filling the follicle Darier dis-covered peculiar refractive double-contoured cells, somewhat larger than anepithelial cell, containing clear or granular protoplasm and large, well-markednuclei, which he, supported by the authority of the biologists Malassez and. -Dariers disease : detail from Fig. 249 in tile stratum granulosum in the middle of the field-so-called psorosperm. Balbiani, regarded as animal parasites—coccidia. Similar cells, or roundbodies, are found in the rete, with the rete-cells arranged concentricallyaround them as in epithelial pearls. The greater mass of the horny plug inthe follicle is made up of cells refractive and homogeneous or containing tracesof a nucleus about half the size of the round bodies. The larger tumor-like masses are papillomatous growths of the same general characters as thelesions elsewhere. The cutis proper is not at all affected or shows but slightinflammatory reaction. According to Darier, the disease, pathologically, is to be regarded as aninfection with psorosperms through the follicles, with irritative disturbancedue to the presence of these organisms. But the majority of observers out-side of France do not sh


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Keywords: ., bookcentury1800, bookdecade1890, booksubject, booksubjectsyphilis