The glands of life : a contribution to the study of organotherapy . will use itsynonymously with infantilism, as usually and Herter showed by some interesting experi-ments that intestinal auto-intoxication may be the onlydiscernible cause for arrested development in some cases,but it is not at all improbable that even in these casesthere is a toxin produced in the intestines which neu-tralizes the normal ergonison of growth which issecreted by the pituitary, and, therefore, these patients,while they may not be primarily suffering from pituitaryderangement, are robbed of its s
The glands of life : a contribution to the study of organotherapy . will use itsynonymously with infantilism, as usually and Herter showed by some interesting experi-ments that intestinal auto-intoxication may be the onlydiscernible cause for arrested development in some cases,but it is not at all improbable that even in these casesthere is a toxin produced in the intestines which neu-tralizes the normal ergonison of growth which issecreted by the pituitary, and, therefore, these patients,while they may not be primarily suffering from pituitaryderangement, are robbed of its stimulating influenceupon their development. Irritations of the sexual organsmay also be responsible for arrested development. Theinternal secretion of the sexual organs is poured out inabnormal amounts which influences the secretion of boththe pituitary and thyroid. The sexual organs increaserapidly in size up to a certain point and the growth isstimulated, precocious puberty is established and devel-opment ceases. The patient is apt to have short legs and (198). Arrested Development 199 more or less square configuration of the body with themental and nervous syndrome which is familiar to us inthis class of cases. On the other hand, the growth maynot be suddenly checked, in which case the individualgrows tall and thin and is asthenic and apathetic. Infantilism may be acquired before puberty, inwhich case the patient is short of stature, feminine inbuild, the hips are broad and the bones small and deli-cate, and the general configuration rounded, resemblingthe female. The voice is apt to be falsetto or highpitched. The subcutaneous adipose tissue is distributedmuch in the manner that it is in the female, especiallyprominent around the hips or gluteal region. The men-tality may be normal, though it is frequently subnormaland seldom strong. The facial expression is inclined tobe docile and apathetic; the skin is delicate, smooth,transparent and dry, and the temperature usuallysubn
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