Transactions of the Royal Society of Edinburgh . the curve indicate the quantities of bile collected every quarter ofan hour. The vertical dotted lines that cross the curves in the illustrationsindicate that something was given to the animal. In all such experiments theamount of bile first collected is usually considerably larger than that atsubsequent periods. This apparently results from the sudden diminution inthe resistance to the exit of the bile consequent upon opening the duct. Thefirst one or two collectionsare therefore not reliable in-dices of secretion, and theyare consequently omit
Transactions of the Royal Society of Edinburgh . the curve indicate the quantities of bile collected every quarter ofan hour. The vertical dotted lines that cross the curves in the illustrationsindicate that something was given to the animal. In all such experiments theamount of bile first collected is usually considerably larger than that atsubsequent periods. This apparently results from the sudden diminution inthe resistance to the exit of the bile consequent upon opening the duct. Thefirst one or two collectionsare therefore not reliable in-dices of secretion, and theyare consequently omittedfrom some of the charts. Experiment 1. Dog thathad fasted eighteen hours. i * e 7 8 hours XXT • 1,4. >i o 1 l ^£ *—Secretion of bile by a fasting dog with nothing but curara ad- Weight 76 kilogrammes. ministered. a, 20 mill. ; b, 2 mill. ; c and d, 4 mill.; c, f, g, 3 mill. —Twenty milligrammes of curara injeoted int0 jugular yein- curara were injected into jugular vein (at a, fig. 1). The abdomen was then VOL. XXIX. PART I. 2 O. 142 PROFESSOR RUTHERFORD ON THE opened, and the cannula placed in the common bile-duct, as above wound in the abdomen was closed, the animal enveloped in cotton wad-ding, and the bile collected. As the experiment proceeded, the effect of thecurara gradually wore off, owing to its elimination, and it was necessary toinject from two to four milligrammes from time to time (b, c, d, e,f, g, fig. 1).If the curve be examined, it will be observed that these doses had no apparenteffect on the biliary secretion, which was in this case tolerably regular. Afterfalling until the middle of the third hour, it increased for a time and then fellsomewhat. At the eighth hour it was slightly below what it had been at theclose of the first. Experiment 2. Dog that had fasted seventeen hours. Weight 18*7 kilo-grammes (fig. 2). As it is evident from thesetwo experiments that dosesof curara such as those givenabove do not apparentlyaffect the biliar
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