The endemic diseases of the southern states . aggerated form or the firstoutbreak may be severe in type. The skin eruption will be more marked and the gastro-in-testinal symptoms more severe, while the nervous and mentalmanifestations will take on a more serious aspect. The disturbances of motility are usually marked, such asmuscular weakness, and even paralysis. The psychic nianifestations are most variable, ranging fromthe deepest depression to great excitability. There may again be periods of remission followed by exacer-bations, each one usually becoming more severe until finally 326 ENDEM


The endemic diseases of the southern states . aggerated form or the firstoutbreak may be severe in type. The skin eruption will be more marked and the gastro-in-testinal symptoms more severe, while the nervous and mentalmanifestations will take on a more serious aspect. The disturbances of motility are usually marked, such asmuscular weakness, and even paralysis. The psychic nianifestations are most variable, ranging fromthe deepest depression to great excitability. There may again be periods of remission followed by exacer-bations, each one usually becoming more severe until finally 326 ENDEMIC DISEASES OF THE SOUTHERN STATES there is a most distressing picture of cachexia, dementia andparalysis and the chapter is closed with death. Incubation Period.—It seems paradoxical to attempt to as-sign an incubation period to a disease about the etiology ofwhich so little is known, and it is a fact that the majority ofwriters who have so assigned an incubation period have doneso on the assumption that the cause of the disease is


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