. The diseases of infancy and childhood : designed for the use of students and practitioners of medicine. Leukemia, Acute, Five Years of Age. Showing Enlargementof Glands of the Neck on Both Sides. DISEASES OF THE BLOOD 731 liver was enlarged below the free border of the ribs to the extent oftwo fingerbreadths; the spleen was enlarged to the level of the umbil-icus; the fundus of the eye showed retinal hemorrhages. Examinationof the blood showed the hemoglobin to be reduced to 15 per cent.(Fleischl). The red blood cells numbered 1,012,000 to the cubicmillimeter; the white blood cells, 37,000.
. The diseases of infancy and childhood : designed for the use of students and practitioners of medicine. Leukemia, Acute, Five Years of Age. Showing Enlargementof Glands of the Neck on Both Sides. DISEASES OF THE BLOOD 731 liver was enlarged below the free border of the ribs to the extent oftwo fingerbreadths; the spleen was enlarged to the level of the umbil-icus; the fundus of the eye showed retinal hemorrhages. Examinationof the blood showed the hemoglobin to be reduced to 15 per cent.(Fleischl). The red blood cells numbered 1,012,000 to the cubicmillimeter; the white blood cells, 37,000. There was an inunensepreponderance of lymphocytes (mononuclear). The patient died withsigns of progressive weakness. Coma was preceded by vomiting andthe appearance of a few petechise. The blood state continued muchthe same as at first. In another case the number of mononuclearlymphocytes was fully 75 per cent, of the white blood Fig. 200.—Acute lymphatic leukemia. Enlarged lymph nodes, spleen, and liver. Boy,aged four and one-half years. In both these cases the spleen and liver diminished in size beforedeath. The proportion of white to red blood cells may not be farfrom normal. In another case the nucleated red blood cells, largeand small, were very numerous. In this case, in a boy of four andone-half years, the nodes around the parotid and angle of the jaw, inthe axilla, and in the inguinal region, increased in a short time to alarge size, and the spleen grew rapidly larger and reached to the crest 7P)2 DISEASES OF LYMPH XODES, DUCTLESS GLAADS AXD BLOOD of the ilium. The liver reached to the umbilicus. These mediastinallymph nodes were enlarged and caused great d>spnea. The distresswas very great just before the lethal issue (Fig. 2110). In a case ofvon Noordens the proportion of the white to the red blood cells was1: 200. The predominance of the lymphocytes is diagnostic. Mostof the cases published sho
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