American practice of surgery : a complete system of the science and art of surgery . amount of exudation is directly proportionate to the extent ofthe w^ound. In wounds which become infected with micro-organisms (septicwounds) the amount of the exudate is dependent upon the extent of the woundand upon the amount of injury due to the action of the toxin produced by themicro-organisms. Within a few hours (twenty-four hours at most) after theappearance of the exudation, there begins a new formation of cells and blood-vessels to replace the lost tissue. The general steps of the process are the sam
American practice of surgery : a complete system of the science and art of surgery . amount of exudation is directly proportionate to the extent ofthe w^ound. In wounds which become infected with micro-organisms (septicwounds) the amount of the exudate is dependent upon the extent of the woundand upon the amount of injury due to the action of the toxin produced by themicro-organisms. Within a few hours (twenty-four hours at most) after theappearance of the exudation, there begins a new formation of cells and blood-vessels to replace the lost tissue. The general steps of the process are the samewhether the edges of the wound can be approximated (incised or closed wound)or cannot be brought together on account of extensive destruction of tissue(lacerated, contused, or open wounds); but there are slight differences in thedetails of the process, as well as in its duration, so that it is customary to de-scribe the healing of aseptic closed, and open wounds separately. Repair of Aseptic Closed Wounds; First Intention.—The histological de- 262 AMERICAN PRACTICE OF .?«©, Ifi,-., ^. f. v^^^. -Ml tails are seen best in experimental wountls on animals. The cellular changesare best studied in a non-vascular organ like the cornea; the vascular changes,in wounds in a relatively simple tissue, such as the ear or tongue of a rabbit. The immediate result of theinjury is hemorrhage. In a fewhours more the space between theapproximated edges is filled withan inflammatory exudate of leu-cocytes, serum, fibrin, and redl)loo(l corpuscles. The exudateextends laterally for some dis-tance into the adjacent tissues,and on the surface coagulatesinto a thin film or crust (scab).The adjacent blood-vessels be-come dilated and contain manyleucocytes. (Fig. 75.) In a few hoius a new forma-tion (proliferation) of the epi-thelial and connective-tissue cellsadjacent to the wound begins.^Mitotic figures appear in the epi-thelium, and the epithelium be-gins to extend over the surfaceof th
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Keywords: ., bookauthorbuckalbe, bookcentury1900, bookdecade1900, bookyear1906
