Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . or 56° C. is inactivatedas a result of destruction of the comple-ment; it still contains, however, the im-mune body. The removal of the lattersubstance from the mixture containing bothis somewhat more complex, but may beaccomplished in the following manner: Ifthe serum of a rabbit immunized to bovinered blood-cells be mixed with the bovine erythrocytes at ordinary tem-peratures, hemolysis occurs; if, however, the mixture is kept at or about0° C., the immune body combines with the cell
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . or 56° C. is inactivatedas a result of destruction of the comple-ment; it still contains, however, the im-mune body. The removal of the lattersubstance from the mixture containing bothis somewhat more complex, but may beaccomplished in the following manner: Ifthe serum of a rabbit immunized to bovinered blood-cells be mixed with the bovine erythrocytes at ordinary tem-peratures, hemolysis occurs; if, however, the mixture is kept at or about0° C., the immune body combines with the cells, hemolysis being preventedby the fact that, at this temperature, the complement is inactive. The redcells may be removed by sedimentation, and if redistributed in a solutioncontaining complement, at the proper temperature, promptly undergohemolysis. It can be shown that the fluid from which the red cellswere removed still retains the complement. The method by whichanticomplement and anti-immune body intervene in the prevention ofhemolysis is indicated by the accompanying diagram (see Figs. 58 and 59).. Cell Kir,. 57.—Diagram Illustrating Views Concerning theUnion between Complement, Im->ruNE Body, and Cell in theProcess of Cytolysis IncludingHemolysis and Bacteriolysis. A, Complement of which B is the zymo-toxic or group and C thehaptophore group which at D joinswith the complementophile group ofthe amboceptor. E, Amboceptor orimmune body of which F is the com-plementophile group and G the cyto-phile haptophoric group. H, Cellreceptor. /, /, Receptors not adaptedto combination with the particularimmune body E, but might combine^\^th other amboceptors possessingappropriate cytophile haptophoricgroups. KACTKKIA AS CAUSES OF DISEASE. 103 The scope of this work does not permit a (hscussion rif the muhi-plicity of comi)lcment or tlie hniitations witliin winch the immune ])0(lvis specific. seem to in(hcate that there is more than onecomple
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