The internal secretions and the principles of medicine . ac-test most actively, thus showing that it wasrich in oxidase—the substnncc which in animals supplied withadrenals I have termed adrenoxidase. As shown by Abelousand Biarnes, this same active reaction was obtained from the *> Howell: Text-book of Physiology, p. 778, 1905. *2 Garnier and Thaon: Jour, de physiol. et path. g6n6r., Mar., 1906. LEUCOCYTES AS DISTRIBUTORS OP POISONS AND REMEDIES. 1053 corresponding blood in crayfish, by Phisalix in batrachians, andso on until the highest inamnials were reached—always withblood derived from
The internal secretions and the principles of medicine . ac-test most actively, thus showing that it wasrich in oxidase—the substnncc which in animals supplied withadrenals I have termed adrenoxidase. As shown by Abelousand Biarnes, this same active reaction was obtained from the *> Howell: Text-book of Physiology, p. 778, 1905. *2 Garnier and Thaon: Jour, de physiol. et path. g6n6r., Mar., 1906. LEUCOCYTES AS DISTRIBUTORS OP POISONS AND REMEDIES. 1053 corresponding blood in crayfish, by Phisalix in batrachians, andso on until the highest inamnials were reached—always withblood derived from the respiratory organs. This interpretation is further sustained by the evident con-nection between the subneural gland—the primitive anteriorpituitary—and the respiratory organs of another ascidian inwhich the duct is very long, PhaUusia mentula. Willey,^^ re-ferring to the structure in which the duct terminates, describesit as the dorsal tubercle, the opening of the hypophysis intothe hranchial sac. Briefly, in the light of my work, in these. atrcav Diagram op the Upper Segment op a Sea-squirt, Illustrating the Connection Between the Pituitary Body (hyp) and the Animals Respiratory Apparatus (stigm). nc. gn., nerve-ganglion or general nerve-center; or. siph., oral siphon; atr. siph.,atrial siphon; tent., tentacles; te.^it, bag; muni., mantle; tr. v., trans-verse vessel; dors, v., dorsal vessel; atr. vav., atrial cavity.(Parker and Uasicell.) invertebrates the ancestral anterior pituitary fulfills the func-tions which in the higher animals are carried on by the adrenals. When does the transition take place ? This question can-not be answered with an}^ degree of accuracy in the light ofavailable knowledge. The adrenals are now thought to occurin the vertebrates only. A study of the question has led meto believe, however, that they appear much earlier, and that inmany invertebrates organs which are now regarded as neph-ridia—and which as such occupy anomalous position
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