. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. REPRODUCTION 69 The cyclical changes in the cell contents of the smear are shown in Figs. 35 and 36, taken from Voss (132). UnpubHshed data obtained at the Jackson Laboratory indicate striking strain differences. However, the cycles shown in Voss's figures may be taken as fairly typical. The smears in terms of which the various stages of the cycle are defined are indicated in Table 4. Of particular interest is the smear characteristic of estrus or heat. The complete or almost complete absence of leu
. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. REPRODUCTION 69 The cyclical changes in the cell contents of the smear are shown in Figs. 35 and 36, taken from Voss (132). UnpubHshed data obtained at the Jackson Laboratory indicate striking strain differences. However, the cycles shown in Voss's figures may be taken as fairly typical. The smears in terms of which the various stages of the cycle are defined are indicated in Table 4. Of particular interest is the smear characteristic of estrus or heat. The complete or almost complete absence of leukocytes from the smear and the presence of cornified cells, in moderate numbers and not clumped, are the (usual criteria of estrus. In one study (126) with MacDowell-Bagg albino mice it was found that the smear at the onset of heat, as determined by PREG. LACTATION 100% 50%- 0%. DAYS 10 -I—I—I—r 20» C 28 A BCD Fig. 36.—Graph showing the percentages of the three types of cells in the vaginal smear of a mouse during a postpartum estrus, lactation, and the normal estrus follow- ing lactation. Smears taken daily. cornified cells, nucleated epithelial cells leukocytes. (A) litter of four born and the beginning of lactation, (B) two young weaned, (C) one more young weaned, (D) last young weaned. Note the incomplete cornification at the post partum estrus and the occurrence of a normal estrus while one young is still nursing. {Voss 1930.) willingness to mate, still contained 5 to 75% of epithelial cells. The smear marking the termination of estrus has not been so accurately determined, but the presence of clumps or sheets of cornified cells is usually regarded as marking the onset of metestrus. A typical late estrus or early metestrus smear is shown in Fig. 34B. The vagina.—No part of the genital tract undergoes more striking histological changes during the estrous cycle than the epithelium of the vagina. The successive stages are shown in Figs. 37 and 38 and sum- marized i
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