SV40 antigen and tumour suppressor. Molecular model of the simian virus (SV40) large T antigen bound to a retinoblastoma tumour suppressor (Rb). Large

---

SV40 antigen and tumour suppressor. Molecular model of the simian virus (SV40) large T antigen bound to a retinoblastoma tumour suppressor (Rb). Large T antigens play a role in regulating the viral life cycle of the polyomaviridae viruses, such as SV40. SV40 is potentially tumour-causing in primates and humans. Rb proteins encourage normal cell cycles, thus preventing the formation of tumours. When the large T antigen binds to Rb, the tumour suppressor's action is blocked, and the development of malignant tumours becomes more likely.

---

Size: 3620px × 4827px
Photo credit: © LAGUNA DESIGN/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: -, 40, antigen, artwork, background, biochemical, biochemistry, biological, biology, complex, cut, cut-, cut-outs, cutout, cutouts, illustration, large, microbiological, microbiology, model, molecular, molecule, outs, polyomaviridae, protein, proteomics, rb, retinoblastoma, simian, structure, suppressor, sv40, tumour, vacuolating, viral, virology, virus, white