. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. PD. 10 mV L 500ms Figure 1. Elevation ofcAMP levels in the STG induces a pyloric rhythm with wuk lateral pyloric constrictor (LP) neuron activity. Intracellular recordings of LP and the pyloric dilator (PD) neuron are shown before and during application of rnM S-Br-cAMP to the crab STG Baseline membrane potentials in control are identical to the trough of the oscillations induced by S-Br-cAMP (LP, - 72 m I', PD. -60 in I'). the effect of dopamine is enhanced by phosphodiesterase inhib- itors (4). These results from the l
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. PD. 10 mV L 500ms Figure 1. Elevation ofcAMP levels in the STG induces a pyloric rhythm with wuk lateral pyloric constrictor (LP) neuron activity. Intracellular recordings of LP and the pyloric dilator (PD) neuron are shown before and during application of rnM S-Br-cAMP to the crab STG Baseline membrane potentials in control are identical to the trough of the oscillations induced by S-Br-cAMP (LP, - 72 m I', PD. -60 in I'). the effect of dopamine is enhanced by phosphodiesterase inhib- itors (4). These results from the lobster, and our results from the crab, strongly implicate a role for cAMP in the modulation of the pyloric motor pattern in the crustacean STG. Because some modulators may act only partly through cAMP, or influence cAMP levels in only some pyloric neurons, we plan to examine the effects of cAMP (and cGMP) on individual neu- rons using intracellular injection. To identify the STG modu- lators that act through cAMP, we also plan to inject peptide inhibitors of the cAMP-dependent kinase. These experiments will help to elucidate the targets and mechanisms through which a large number of neuromodulators are capable of tailoring the rhythmic activity of the STG to an ever-changing environment. We thank the Grass Instrument Co., Dan Johnston, and Ron Calabrese for the loan of valuable equipment. This work was supported by a Grass Fellowship to NS and BNS-8909613 (NSF) and NS29436 (NIH) to MPN. Literature Cited 1. Selverston, A. I., and M. Moulins. 1987. The Crustacean Sto- matogastric System. Springer-Verlag, Heidelberg. 2. Marder, E., and J. M. VVeimann. 1991. In Neurobiology oj Motor Programme Selection: New Approaches to Mechanisms oj Behavioral Choice. J. Kein. C. McCrohan. and B. Winlow, eds. Manchester. University Press. 3. Flamm, R. E., el al. 1987. / Keiirophysiol. 58: 1370-1386. 4. Ewald, D. A., and D. L. Barker. 1987. Pp. 301-303 in The Crus- tacean Stomatogastnc System Spri
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