. The endocrine organs; an introduction to the study of internal secretion . cupied by an oxyphil colloid material:occasionally these vesicles are unusually large and numerous, especiallyin the neighbourhood of the intraglandular cleft (fig. 52). In addition tothese colloid masses, some of the cells of the pars intermedia may oftenbe seen in different stages of conversion into globular hyaline bodies, theirprotoplasm and nucleus becoming swollen: the latter may have becomeindistinct or have disappeared. Some of the globules thus produced are Structure of the Pituitary 81 granular in character
. The endocrine organs; an introduction to the study of internal secretion . cupied by an oxyphil colloid material:occasionally these vesicles are unusually large and numerous, especiallyin the neighbourhood of the intraglandular cleft (fig. 52). In addition tothese colloid masses, some of the cells of the pars intermedia may oftenbe seen in different stages of conversion into globular hyaline bodies, theirprotoplasm and nucleus becoming swollen: the latter may have becomeindistinct or have disappeared. Some of the globules thus produced are Structure of the Pituitary 81 granular in character rather than hyaline. In both cases the cells ultimatelybreak down, setting free the hyaline or granular substance. As has already been mentioned, the pars intermedia is by no means every-where sharply marked off from the pars nervosa, for strands of the cellsof the pars intermedia may extend a variable distance between the fibresof the pars nervosa. The hyaline and granular globules which have beenderived from its cells also pass into the substance of the pars nervosa and. FIG. 52.—Portion of pars anterior of cats pituitary, showing the groups ofoxyphil cells with vascular spaces between the groups. Several vesicles,surrounded by cells, are included in the section. Magnified 400 diameters. are seen between its fibres: they can, in fact, be traced as far as the con-tinuation of the third ventricle into the stalk. This fact was pointed outby Herring, who concluded that the hyaline and granular substances whichare produced by conversion and breaking down of the cells of the parsintermedia form the secretion of this portion of the pituitary, and that thissecretion passes into the cerebro-spinal fluid. In confirmation of Herringsconclusion, evidence that the active principle of the posterior lobe of thepituitary is present in cerebro-spinal fluid has been obtained by Gushingand Goetsch, although their results have been traversed by Carlson. Ithas, however, been shown by Cow that i
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