. The thyroid gland in health and disease. Fig. 33.—Large congenital goitre in premattirely-born goat; experimentally-produced. The animal was quite hairless. (Reproduced by courtesy of the Editor of the Practitioner.) (8) Goitre has been produced experimentally in animals— rats and goats—by feeding them on cultures, from thefaeces of goitrous and non-goitrous subjects, grownunder aerobic and anaerobic conditions : those grownunder anaerobic conditions being the more potent inthis respect. [9, 10, 20.] (9) Congenital goitre (fig. 33), cretinism (fig. 34), and congenital CAUSAL AGENT OR AGENTS
. The thyroid gland in health and disease. Fig. 33.—Large congenital goitre in premattirely-born goat; experimentally-produced. The animal was quite hairless. (Reproduced by courtesy of the Editor of the Practitioner.) (8) Goitre has been produced experimentally in animals— rats and goats—by feeding them on cultures, from thefaeces of goitrous and non-goitrous subjects, grownunder aerobic and anaerobic conditions : those grownunder anaerobic conditions being the more potent inthis respect. [9, 10, 20.] (9) Congenital goitre (fig. 33), cretinism (fig. 34), and congenital CAUSAL AGENT OR AGENTS OF GOITRE 99 parathyroid disease (figs. 65-67), have been producedexperimentally in the offspring of such animals bycontinuing to feed the mothers throughout pregnancywith these cultures. [16, 24, 25.](10) Finally, vaccines prepared from intestinal organisms arecapable of causing the disappearance of recent cases of. Experimentally-produced Cretinism. Fig. 34.—Litter of three young rats, aged 20 days ; the offspring of a motherwhich consumed goitrous fsecal filtrate prior to, and during, pregnancy. Theanimal in the centre is a cretin. Note stunted growth and curvature of spine. goitre when injected in appropriate doses at weeklyintervals (figs. 37, 48). [14.]This accumulation of facts demonstrates, I believe, thatthe causal agents of goitre, as well as of its congenital mani-festations, are micro-organisms inhabiting the alimentary tract 100 ENDEMIC GOITRE of sufferers from this disease, and often of other persons whosethyroids show no actual enlargement, but which neverthelessmay be in a hyperplastic state. Except in so far that all theepidemiological and experimental facts point to anaerobic organ-isms as the causal agents of this disease, they do not permit of amore definite conclusion as to the identity of these organisms. It is amply proven also that the changes characteristic ofparenchymat
Size: 1619px × 1543px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookdecade1910, bookpublishernewyorkwilliamwood
