. On the Action of Cobra Venom. Parts I and II. d was accompanied by higher tone, which lasted for some time, aiid then gave placeto relaxation. The pendulum movements became smaller and the intestine reached beyond itsnormal length, and afterwards did not respond to the addition of 1 : 10,000 bariumchloride, which has a distinct augmentor effect on the normal intestine. Atropinehad no influence on the augmentor nor on the depressor phase of the action. I foundthat prolonged and repeated washing of the preparation had very little effect inremoving the venom action when it had once been elicite
. On the Action of Cobra Venom. Parts I and II. d was accompanied by higher tone, which lasted for some time, aiid then gave placeto relaxation. The pendulum movements became smaller and the intestine reached beyond itsnormal length, and afterwards did not respond to the addition of 1 : 10,000 bariumchloride, which has a distinct augmentor effect on the normal intestine. Atropinehad no influence on the augmentor nor on the depressor phase of the action. I foundthat prolonged and repeated washing of the preparation had very little effect inremoving the venom action when it had once been elicited in full strength. The same effects were produced in the intestine of the frog, guinea-pig, and cat,and also in the colon of the rabbit suspended in the same way. The action on the ?^ Trendelenburg, *Zeitsch. f. Biol., vol 61, p. 67 (1913). 32 PEOF. A. R. CUSHNY AND DE. S. YAGI intestine, like that on the stomach, thus consists of a primary phase of increased toneand increased movement, followed by one of relaxation and paralysis when large. Fia. 9.—Action of venom (1 : 100,000) on surviving intestine of rabbit in Eingers solution. amounts of the poison are employed. In experiments on the gut of the rabbit andcat, carried out in the same way as mine, Gunn observed only a depressor action andarrest of the movements. But he seems to have generally used very much higherconcentrations than I found necessary, such as 1: 10,000-25,000. In one tracing
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