. A text-book of bacteriology; a practical treatise for students and practitioners of medicine. Bacteriology. LYSINS, AGGLUTININS, PRECIPITINS, ETC. 245 inactivated bactericidal immune serum (immune body), and comple- ment in the test tube, a great excess of immune body hindered rather than helped bactericidal action. As the amount of immune body in the mixture was carried beyond the experimental optimum, bac- tericidal action became less and less pronounced, and was finally completely suspended. They explain this by assuming that free im- mune body, uncombined with complement, has a greater a
. A text-book of bacteriology; a practical treatise for students and practitioners of medicine. Bacteriology. LYSINS, AGGLUTININS, PRECIPITINS, ETC. 245 inactivated bactericidal immune serum (immune body), and comple- ment in the test tube, a great excess of immune body hindered rather than helped bactericidal action. As the amount of immune body in the mixture was carried beyond the experimental optimum, bac- tericidal action became less and less pronounced, and was finally completely suspended. They explain this by assuming that free im- mune body, uncombined with complement, has a greater affinity for the bacterial receptor than the immune body combined with complement. The complement is consequently diverted and prevented from activating the amboceptor attached to the bacterial cell. Graphically, the con- ditions may be illustrated as follows: â .^UjU^ -^y^ ^gu^. Fig. 63. â Neisser and Wechsbekg's Conception of Complement Deviation. The above theory of Neisser and Wechsberg is here stated simply because of the wide discussion it has aroused. In the light of our present knowledge concerning the relations between antigen, amboceptor, and complement, their conception is obviously Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Hiss, Philip Hanson, 1868-1913; Zinsser, Hans, 1878-1940. joint author. New York and London, D. Appleton and Company
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