Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (blue) bound to a p53 peptide (pink). Sir2 enzymes form a unique class of NAD(+)-d

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Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (blue) bound to a p53 peptide (pink). Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases that are required for diverse biological processes, including transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilisation, and lifespan regulation. NAD is shown as a stick model (centre). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA.

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Size: 3623px × 4830px
Photo credit: © RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

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