Annals of medical history . nefrom the Cretaceous of Kansas and certaincrocodile limb bones from the Jurassic ofEngland show lesions of a necrotic assignment ofany of the lesionsto a definite causeis manifestly im-possible, and whiletuberculosis hasbeen suggested asa possible cause,the diagnosis is souncertain as to benearly the crocodileskeleton, abovereferred to, thereis abundant evi-dence that the in-fection, the focusof which was inthe pelvis, wascarried by metas-tasis to the bonesof the palate whichwere also involved,as well as otherparts of the Hyperosto-


Annals of medical history . nefrom the Cretaceous of Kansas and certaincrocodile limb bones from the Jurassic ofEngland show lesions of a necrotic assignment ofany of the lesionsto a definite causeis manifestly im-possible, and whiletuberculosis hasbeen suggested asa possible cause,the diagnosis is souncertain as to benearly the crocodileskeleton, abovereferred to, thereis abundant evi-dence that the in-fection, the focusof which was inthe pelvis, wascarried by metas-tasis to the bonesof the palate whichwere also involved,as well as otherparts of the Hyperosto-sis or PACHYOSTO- sis, which is similarto the enlargementof the bones inGigantism, is indi-cated as thickenedand enlarged por-tions of the skel-eton. This condi-tion has been de-tected in certainfossil Paleozoicfishes and Mesozoicreptiles, some of them of great geologicalantiquity. A genus of fossil whales, knownas Pachycanthus, has the neural, vertebralspines very greatly enlarged and swollen. 392 Annals of Medical History. - Fig. 19. Microscopic section of one of the lesionsfrom the surface of the humerus, Fig. IS, showingbundles of perforating fibers of Sharpey, osseouslacuna?, and vascular openings. The large clearspace at the upper portion of the picture is a vascu-lar opening filled with calcite crystals. 300 diameters. A similiar condition is seen in the skeletonof a Triassic nothosaur. Wre are not justifiedin stating on these evidences the presence ofpituitary disturbances in ancient animals,but further studies in this line may addvery interesting data. 12. Osteoperiostitis or some similar dis-turbance is the result seen in the arm bonesof a mosasaur from the Cretaceous ofKansas (Fig. 18). The articular surfacesare very greatly roughened and the surfacesof the bones are covered with smooth,somewhat flattened excrescences, possiblydue to a subperiosteal irritation. The lesionshave been observed in no other instances,so that no comparative statements can bemade. Microscop


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Keywords: ., bookauthorp, bookcentury1900, bookdecade1910, booksubjectmedicine