. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. DISCUSSION 345 During the first phase the newborn is not immunologically compe- tent; it provides only a nutrient medium and an antigenic stimulus to the immunologically competent injected cells. In turn, these cells react against the host and they can do so in two ways, leading respectively to a rejection reaction and a facilitation reaction. A competition takes place between these two reactions for rapidity of appearance and/or intensity. Nnl\ge^">c Stimufus. Rejection predominates over Facilitat
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. DISCUSSION 345 During the first phase the newborn is not immunologically compe- tent; it provides only a nutrient medium and an antigenic stimulus to the immunologically competent injected cells. In turn, these cells react against the host and they can do so in two ways, leading respectively to a rejection reaction and a facilitation reaction. A competition takes place between these two reactions for rapidity of appearance and/or intensity. Nnl\ge^">c Stimufus. Rejection predominates over Facilitation Fig. 2 (Voisin). Phase I (cells versus host). Predominance of the rejection reaction over the facihtation reaction, leading to runting. During the second phase, that competition can continue, but now the young animal becomes immunologically competent and starts to respond to the antigenic stimulus of the injected homologous cells; this immunological response can also be exerted in two ways—rejection and facilitation. Here again a competition takes place. The direct logical consequences of the hypothesis are rather obvious. During phase I, if the rejection reaction of the injected cells towards the homologous newborn predominates over the facilitation reaction, the animal will be runted and eventually die (Fig. 2); if the facilitation. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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