Transactions of the Royal Society of Edinburgh . erty, and had not Rohrig stated (Op. vi.) thatit excites the liver as much as rhubarb, we should not have deemed its powersworthy of investigation. The ordinary infusion of senna of the British Pharma- Experiment 15. Secretion Secretion Secretion of bile per Secretion of bile per of bile per kilogramme of bile per kilogramme 15. of dog : per 15. of dog : per cc. hour. hour. cc. 1-2 \ 1-2 1-2 1-3 > 0-212 cc. 1-2 1-2 ) 13 r 1-2 1-2 1-5 1-1 1-3 1-15 1-17 1-2 s 1-2 1-2 s 13 \ 1-212 1-415 [ 0-238 cc. 1-1 - 1-3 ) 1-3 12 1-4 * 1-2 1-1 1-5 1-2 1-3 1
Transactions of the Royal Society of Edinburgh . erty, and had not Rohrig stated (Op. vi.) thatit excites the liver as much as rhubarb, we should not have deemed its powersworthy of investigation. The ordinary infusion of senna of the British Pharma- Experiment 15. Secretion Secretion Secretion of bile per Secretion of bile per of bile per kilogramme of bile per kilogramme 15. of dog : per 15. of dog : per cc. hour. hour. cc. 1-2 \ 1-2 1-2 1-3 > 0-212 cc. 1-2 1-2 ) 13 r 1-2 1-2 1-5 1-1 1-3 1-15 1-17 1-2 s 1-2 1-2 s 13 \ 1-212 1-415 [ 0-238 cc. 1-1 - 1-3 ) 1-3 12 1-4 * 1-2 1-1 1-5 1-2 1-3 1 1-0 PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 161 copoeia was prepared and concentrated until 5 cc. contained the active part offorty-five grains of senna ; a small dose for a man. Experiment 15. Dog that had fasted eighteen hours. Weight 231 kilo-grammes.—\ cc. bile and 5 cc. water were injected into duodenum at b (tig,15), and \ cc. bile, with 5 cc. infu-sion of senna of the strength above slight increase Therethe in hadength. Fig. 16.—Secretion of bile before and after 60 grains extractof colchicum in 10 cc. water were injected into theduodenum at c. mentioned, at s, swas only abiliary secretion. Necropsy. — The sennapassed through the wholeof the small and had entered thelarge intestine. The amount offluid in the small intestine was103 cc, showing that a very con-siderable purgative effect had beenproduced. Result of Experiment ivithSenna. — Although senna is apowerful intestinal, it is a veryfeeble hepatic stimulant. Rohrigserror with regard to it was doubt-less the result of his faulty method. Action of Colchicum. Colchicum has been recom-mended by Garrod as a chola-gogue in cases of gout, but itsaction on the liver has not hithertobeen tested by direct grains of the extract is themaximum dose for a man. Experiment 16. Dog that hadfasted sixteen hours. Weight 23*5kilogrammes.—Sixty grains of theaqueous extract of colchicum of theBri
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