Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ateral pressure, pressure from in frontor the development of a thyroid tumorin the submucosa (intratracheal goiter).Lingual goiter may obstruct the pharynxor encroach upon the laryngeal goiter may press upon thelower trachea, bronchi, or other intrathoracic structures. Exophthalmic goiter,^ also called Gravess disease, or Basedowsdisease, is an affection of unknown etiology, usually characterized byexophthalmos (prominence of the eyeballs), tachycardia, a peculiarf
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . ateral pressure, pressure from in frontor the development of a thyroid tumorin the submucosa (intratracheal goiter).Lingual goiter may obstruct the pharynxor encroach upon the laryngeal goiter may press upon thelower trachea, bronchi, or other intrathoracic structures. Exophthalmic goiter,^ also called Gravess disease, or Basedowsdisease, is an affection of unknown etiology, usually characterized byexophthalmos (prominence of the eyeballs), tachycardia, a peculiarform of muscular tremor, and enlargement of the thyroid gland; one ormore of these so-called cardinal symptoms may be absent. It is clearlyan intoxication—a toxemia; the character and origin of the poison arenot definitely known, but the facts at our disposal indicate that it is 1 Kocher, Ueber Morbus Basedowi, 1902; 1423 references. Murray, Lan-cet, Dec. 13, 1902, p. 1612. Salmon, Clin. Med., Aug. 3, 1904. Jellinck,Wien. klin. Woch., Oct. 27, 1904. MacCallum and Cornell, Med. News,Oct. 15, 1904, p. Fig. 381.—Goiter (Bilateral) CausingCompression of the Windpipe Produc-ing THE So-called Bayonet-shapedTrachea.—{Demme, courtesy of ) DUCTLI-;SS 783 some prodiut, normal or abnormal, of the tliyroid gland. When anexcess of thvroid secretion is absorbed, symptoms resembling somefeaturis <if (iravcss disease may occur, and constitute what is calledhyperthyroidism or thyroidismus; these phenomena may be experi-mentallv ])roduced, follow operations in which thyroid secretion escapesinto the wound, or be due to other injuries of the gland. In Basedowsdisease the blood content of the thyroid is increased, and hyperplasia ofthe epithelium of the acini is usually present, although there is noabsolutely constant anatomic alteration in the gland. MacCallum andCornell conclude that no adequate explanation has been given for theexophthalmos. Tumors of the Th
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