. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. RADIOACTIVE TRACERS 855 The ratio of the rate of incorporation of ^^p or ^^C into DNA and RNA in the exposed organism shows appreciable variations. These depend on the nature of the precursor, the time left for the labelled compound to take part in the metabolic steps involved and the dilution of the newly- formed labelled DNA or RNA by "old" non-labelled ones present. As the InTest. mucosa ONA Protein Liver ONA Protein o Muscles Kidneys DNA Protein- DNA Protein c o O Fig. 1. Effect of irradiation, 700 r X-ray
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. RADIOACTIVE TRACERS 855 The ratio of the rate of incorporation of ^^p or ^^C into DNA and RNA in the exposed organism shows appreciable variations. These depend on the nature of the precursor, the time left for the labelled compound to take part in the metabolic steps involved and the dilution of the newly- formed labelled DNA or RNA by "old" non-labelled ones present. As the InTest. mucosa ONA Protein Liver ONA Protein o Muscles Kidneys DNA Protein- DNA Protein c o O Fig. 1. Effect of irradiation, 700 r X-rays, on the incorporation of "C of injected CHg^COONa into tissue fractions of the growing mouse. 300 olOO. days Fig. 2. Effect of irradiation on the incorporation of ^^P into the DNA of the spleen of the rat (Kelly et al.) total RNA content shows greater variations with time than that of the DNA content, the dilution effect will show a more intricate pattern in the case of RNA than in that of DNA. The great difference in the synthetic rate of nuclear and cytoplasmic PNA will also contribute to make the effect of irradiation on the incorporation of ^^p or i^C into PNA much more dependent from the experimental conditions than that into DNA. While the effect of irradiation on PNA formation is mostly less pro- nounced than on DNA formation, this interference may have very far reaching consequences as Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Hevesy, Georg von, 1885-1966. New York, Pergamon Press
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