. Activities handbook. Veterinary medicine. All EniciUa abortus strain 19 vaccine pro- duced in the United States for use in State- Federal brucellosis eradication is examined at Heltsville before release. Vaccines that do not meet the rigid requirements for purity, hy- drogen ion concentration (pH), total cell con- centration, viability, and colonial characteris- tics are rejected. During the year, 1,516 serial lots, i-epresenting 8,604,946 , were tested. Of this amount, more than 7,949,876 doses ( percent) were released as safe and reli- able for use. There has been a gradual in- c
. Activities handbook. Veterinary medicine. All EniciUa abortus strain 19 vaccine pro- duced in the United States for use in State- Federal brucellosis eradication is examined at Heltsville before release. Vaccines that do not meet the rigid requirements for purity, hy- drogen ion concentration (pH), total cell con- centration, viability, and colonial characteris- tics are rejected. During the year, 1,516 serial lots, i-epresenting 8,604,946 , were tested. Of this amount, more than 7,949,876 doses ( percent) were released as safe and reli- able for use. There has been a gradual in- crease in volume production of desiccated strain 19 vaccine (lyophilized) since the re- lease of this i)roduct in 1945. Eighty-six per- cent of the 43,024,733 milliliters produced in 1960 were desiccated vaccines. Brucella abortus Strain 19 VACCINE RELEASED FOLLOWING TEST Ml I. DOSES. 1950 1953 1959 US oeParthcmto^aomiculTure ? SHICULtUtttL HtSCKCH SCKVlCC In addition to the Brucella strain 19 vaccine (liquid) produced at Beltsville for reference purposes, 840 doses were distributed for vac- cinating calves in 19 Federal herds. On numerous occasions, cultures of the or- ganism causing brucellosis have been supplied to private and Government laboratories in the United States and in many foi'eign countI'ies. To replace stock cultures for use in produc- ing the vaccine, continuous since the jjrocedure was inaugurated in 1940, 107 selected Brucella abortus strain 19 cultures were supplied to 17 commercial laboratories and 2 State tions during 1960, and 106 selected cultures were sent to 17 foreign countries. Of the 213 cultures di.'^tributed, 50 percent were furnished for distribution outside the continental United States. Thirty-six selected cultures of Brucella abortus antigen strain 1119-3 were distributed to 1 States and 10 foreign countries for use in producing antigens and for research pur- poses. Stock cultures of Brucella abortus .strains 19 and 1119-3
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