. The actinomycetes. Actinomycetales. NHCO. CH2—CH=C(CH3)2 The sugar, which is called noviose, includes a methoxyl and a carbamate group. In dilute alkali reaction, the carbamate group is shifted to the carbon indicated l)y a star to form an isomer of novobiocin, isonovol)io- cin, which is biologically inactive. Hygromycin is a weakly acidic sul)stance which is active against bacteria and is also toxic to worms. Its molecule is formed of three cyclic moieties: (1) an aminated inosi- tol moiety which is believed to have a meth- ylenedioxy group attached, (2) a hydrox- ylated and methylated cinn
. The actinomycetes. Actinomycetales. NHCO. CH2—CH=C(CH3)2 The sugar, which is called noviose, includes a methoxyl and a carbamate group. In dilute alkali reaction, the carbamate group is shifted to the carbon indicated l)y a star to form an isomer of novobiocin, isonovol)io- cin, which is biologically inactive. Hygromycin is a weakly acidic sul)stance which is active against bacteria and is also toxic to worms. Its molecule is formed of three cyclic moieties: (1) an aminated inosi- tol moiety which is believed to have a meth- ylenedioxy group attached, (2) a hydrox- ylated and methylated cinnamic acid moiety, and (8) a hexose (5-keto-()-desoxyarabo- hexose): OH CH3—CO- O -/ N- drolysis of the mixture yields D-araljinose, glucose, mannose, rhamnose, and a ninhy- drin-positive sul)stance. Strcptothricins Strcptothricin was the first basic, water- solui)le antibiotic with activity against gram-positive and gram-negative bacteria to be isolated. Because of its toxicity it was never used clinically. As explained in greater detail in Part B of this book, a large number of substances closely related to strcptothricin have been isolated. All the "streptothricin type" anti- biotics yield on hydrolysis a mixtiu'c of OH CH3 -0- .CH=C—CO—NH/ OH OH OH OH O— Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Waksman, Selman A. (Selman Abraham), 1888-1973. Baltimore, Williams & Wilkins
Size: 2004px × 1247px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookcoll, bookpublisherbaltimorewilliamswilkins
