Archives of internal medicine . poorly formed. This condition is readily seen in Figure 3, aphotograph of the two embryos. The abnormal one has small hind legs,and one of them is badly folded under its body. This is of interest, sinceall of the affected offspring of alcoholic guinea-pigs are weak in theirhind extremities and drag their legs. Yet none were so modified as toshow a noticeable structural defect except this embryo, which had onealcoholic grandmother and an alcoholic father. 392 IRCH1VE8 OF IXTERXAL //:///7 \/•: The only other survivor from an alcoholic mother is strong and fullgrow
Archives of internal medicine . poorly formed. This condition is readily seen in Figure 3, aphotograph of the two embryos. The abnormal one has small hind legs,and one of them is badly folded under its body. This is of interest, sinceall of the affected offspring of alcoholic guinea-pigs are weak in theirhind extremities and drag their legs. Yet none were so modified as toshow a noticeable structural defect except this embryo, which had onealcoholic grandmother and an alcoholic father. 392 IRCH1VE8 OF IXTERXAL //:///7 \/•: The only other survivor from an alcoholic mother is strong and fullgrown for its age. The mother had been treated for only two and <»n<-half months when the offspring was born, so thai she was normal duringthe two iir three weeks f pregnancy. No doubl the early stagesof developmenl are more easily modified t<» produce significanl defectsthan are the later. This question is being more fully tested on guinea-pigs with experiments qow in progress. I have shown, however, in. Fig. i. \. The animal on the lefl is .> run! from ;> large alcoholic male large normal female; weighs 134 gm. The animal on the right, from normalparents, is larger although I month youngei and weighs I 17 uin. B. The guinea pig on the lefl ia ;i runt, weighing 132 gm, from an alcoholic father; on the li^ht ;i mal guinea pig i vice aa large though onlj I11 days older, weighs 221 gm. treating fish eggs thai the period a1 which the treatmenl is applied is a mo8l importanl factoi in determining the type of defecl or i lifii which will result. Certain salts, diflFerenl strengths of magnesiumchlorid, for example, which Lri\r pronounced effects when added to the CHARLES R. STOCKARD 393 sea-water containing eggs in early developmental stages, may really beineffective after the eggs have developed beyond these stages. In theease under consideration the offspring might noi have fared so well ifthe alcoholic treatment had been started on the mother a few week
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