The malarial fevers, haemoglobinuric fever and the blood protozoa of man . conclusiveevidence that Glossinapalpalis is the intermediate host of Trypanosoma observations of Koch and Gray and Tulloch appeared for a while toindicate that this trypanosome underwent sexual development in the stomachof Gl. palpalis, but the careful work of Novy upon the trypanosomes of tsetseflies proved beyond question that the trypanosomes studied by the investigatorsmentioned were peculiar to tsetse flies and had no relation whatever to Trypano-soma gambiense. In a later paper by Minchin, Gray, and
The malarial fevers, haemoglobinuric fever and the blood protozoa of man . conclusiveevidence that Glossinapalpalis is the intermediate host of Trypanosoma observations of Koch and Gray and Tulloch appeared for a while toindicate that this trypanosome underwent sexual development in the stomachof Gl. palpalis, but the careful work of Novy upon the trypanosomes of tsetseflies proved beyond question that the trypanosomes studied by the investigatorsmentioned were peculiar to tsetse flies and had no relation whatever to Trypano-soma gambiense. In a later paper by Minchin, Gray, and Tulloch, theseauthors say, We are, therefore, now convinced from the results of these numer-ous experiments that the trypanosomes found in the freshly caught flies havenothing to do with sleeping sickness and are not developmental stages of ^ These authors also found that flies infected with this trypano-some were not infective after 48 hours, and while they describe sexual forms inthe fly they are the same that occur in blood films from man. At the present. a be Fig. 28.— Trypanosoma , Trypanosoma gambiense, after Button. B, Trypanosoma gambiense, after , Trypanosoma gambiense, after Liihe. time, therefore, there is no evidence that the tsetse-fly is the intermediate hostof Trypanosoma gambiense, but that this insect transmits the infection directly,no sexual cycle being necessary before the trypanosome becomes does not, however, preclude the existence of a true intermediate host forthis trypanosome. The observations of Salvin-Moore and Breinl regarding aresistant form of Trypanosoma gambiense which they observed in infected rats,have not as yet been confirmed, but are worthy of further investigation. Inrats infected with Trypanosoma gambiense they observed in the lungs, bone-marrow, and spleen, small round bodies, consisting of protoplasm and nucleus,which they claim are derived from the trypanosomes. Under favorable condi-tions
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