Transactions of the Royal Society of Edinburgh . Fig. 29. —Secretion of bile before and after iridin. 2 cc. bile and 3 injected into the duodenum at b. 5 grains iridin in thesame fluid injected at i. Experiment 29. Secretion of bile Secretion of bile per 15. per kilogramme ofdog: per liour. cc. 1-8 11 1-25 1-0 1-15 b 1-5 \ 1-16 1-3 >0-227cc. 1-2 ) i 1-4 1-25 1-45 13 1-55 1-55 2 75 2-45 2-8 \ 4-02-65 > 0-537 cc. 275 ) 2-4 25 2-1 2 4 2-6 2-3 15 1-3 Necropsy.—Stomach normal. Mucous membrane of upper two-thirds ofsmall intestine rather more vascular than usual. This portion of the i
Transactions of the Royal Society of Edinburgh . Fig. 29. —Secretion of bile before and after iridin. 2 cc. bile and 3 injected into the duodenum at b. 5 grains iridin in thesame fluid injected at i. Experiment 29. Secretion of bile Secretion of bile per 15. per kilogramme ofdog: per liour. cc. 1-8 11 1-25 1-0 1-15 b 1-5 \ 1-16 1-3 >0-227cc. 1-2 ) i 1-4 1-25 1-45 13 1-55 1-55 2 75 2-45 2-8 \ 4-02-65 > 0-537 cc. 275 ) 2-4 25 2-1 2 4 2-6 2-3 15 1-3 Necropsy.—Stomach normal. Mucous membrane of upper two-thirds ofsmall intestine rather more vascular than usual. This portion of the intestinecontained 63 cc. of fluid, thus affording evidence of a decided purgativeeffect. Experiment 30. Dog that had fasted eighteen hours. Weight kilo-grammes (fig. 30).—2 cc. bile and 2 cc. water injected into the duodenum at same with 5 grains of iridin injected at i. PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 175. Fig. 30.—Secretion of bile before and after iridin. 2cc. bile anl injected into the duodenum at h. 5 grains iridin in thesame fluid injected at i. Necropsy.—Stomach normal. There was increased vascularity of themucous membrane of nearly the whole length of the small intestine. Theredness was not very marked, but it was greater than in the previous experi-ment. There was decided purgation, the small intestine containing 87 cc. offluid with abundant mucousflocculi. Results of Experiments withIridin.—1. Five grains of iridinwhen mixed with a little bileand water and placed in theduodenum very powerfullystimulated the liver. It is notso powerful as large doses(four grains) of podophyllin,but it is more powerful thaneuonymin, as is shown by theamount of bile secreted perkilogramme of clog; the hourlycoefficients of secretion forthe two euonymin experimentsbeing 0*4789 cc. and 04678 cc,whereas in the iridin experi-ments they are 0537 cc. and0*638 cc. respectively. Thehigh co
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