Modern surgery, general and operative . the softenedarea. If improvement is to occur it usually begins in from one to fourweeks. If there is no improvement within four weeks there probably will notbe any. In most cases as injection is continued susceptibility diminishes; insome few, it increases. It seems definitely proved that cases are occasionallycured by Coleys fluid. It is generally stated that spindle-cell sarcomata areinfluenced most favorably and that round-celled sarcomata are very in a study of 91 cases regards the small round-cell sarcomata as mostamenable to the t
Modern surgery, general and operative . the softenedarea. If improvement is to occur it usually begins in from one to fourweeks. If there is no improvement within four weeks there probably will notbe any. In most cases as injection is continued susceptibility diminishes; insome few, it increases. It seems definitely proved that cases are occasionallycured by Coleys fluid. It is generally stated that spindle-cell sarcomata areinfluenced most favorably and that round-celled sarcomata are very in a study of 91 cases regards the small round-cell sarcomata as mostamenable to the treatment, spindle-cell sarcomata as coming closely next, andthe mixed-cell type as decidedly refractory (Boston Med. and Surg. Jour.,Jan., 1915, clxxii). Cancers are seldom benefited. The method is not entirelyfree from danger, but the danger is very slight if treatment is begun with theminimum dose. The toxins seem of value in postoperative cases to preventrecurrence. For this purpose the fluid is used twice a week for several Fig. 204.—Huge sarcoma of buttock cured by partial extirpation and Coleys fluid. and at greater intervals for a long period of time. During the autumn of 191aI brought before my class in the Jefferson Hospital a colored woman (Fig. 204)with an inoperable spindle-cell sarcoma of the thigh and groin. A portion ofthe growth was removed and the remainder completely disappeared from injec-tions of Coleys fluid. She remained well over three years after treatment wassuspended when I lost sight of her. This patient had a violent reaction everyday for weeks. She was given as much as 7 min. at a dose. How the toxins act is uncertain. They produce some change in the blood-serum, and the valuable effect is systemic. Nearly always they cause leuko-cytosis. Probably they cause the formation of antibodies antagonistic to thesarcoma cells. The treatment, as Coley insists, is not a substitute for fluid is used in inoperable cases, a trial of it i
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