A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . cle. From a chemicalstandpoint, there seems to be reason for placingsome faith in this theory, inasmuch as nuclein can bedemonstrated in considerable quantities in adulterythrocytes. Postnatal Origin of Erythrocytes.—As has beensuggested in the previous section, the hemopoieticfunction of the spleen probablv ceases at. or shortlyafter, birth at full term, and tliere is much evidenceto show that this organ does not again play a part inred corpuscle formation, except
A reference handbook of the medical sciences, embracing the entire range of scientific and practical medicine and allied science . cle. From a chemicalstandpoint, there seems to be reason for placingsome faith in this theory, inasmuch as nuclein can bedemonstrated in considerable quantities in adulterythrocytes. Postnatal Origin of Erythrocytes.—As has beensuggested in the previous section, the hemopoieticfunction of the spleen probablv ceases at. or shortlyafter, birth at full term, and tliere is much evidenceto show that this organ does not again play a part inred corpuscle formation, except possibly aftersevere hemorrhage, or in such conditions as perniciousanemia, where there is an abnormal demand fornew corpuscles. Regarding the place of origin afterbirth, it is now generalh admitted that the red bonemarrow is the seat of their most abundant production. REFERENCE HANDBOOK OF THE MEDICAL SCIENCES Blood Their formation in this location doubfloss commencesduring the last few weeks of intravitcrine life, over-lapping somewhat the diminishing efforts of the spleenin this direction. Here again, however, there is. Fig. 696.—From the Bone Sfarrow of the Dog. X 1,200 times.(From Boehm and von Davidoff, after H. F. Muller.) a, Masfzelle;b, lymphocyte: c, leucocyte with acidophile granules: (/.non-nucle-ated blood corpuscle; e, nucleated red corpuscle in the act ofdi\iding: /, nucleated red corpuscle. Many other theories are still maintained as to theorigin of the nucleated erythrocytes of the marrow,among which may be mentioned that of Osier. Hecontends that they arise from still another type ofhyaline cell of the bone marrow. Bizzozero, Schafor,and others hold that tliey are the result of mitoticdivision of similar emliryonic cells which are broughtfrom the liver and spleen when the red marrow beginsto develop. Obrastzow believes that the red blooddiscs are formed from the nuclei of hyaline cells of thered marrow, without, however, passing through thenucleated stage
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