Electrolytes in biological systems, incorporating Electrolytes in biological systems, incorporating papers presented at a symposium at the Marine Biological Laboratory in Woods Hole, Massachusetts, on September 8, 1954 electrolytesinbi00shan Year: 1955 226 ELECTROLYTES IN BIOLOGICAL SYSTEMS has now arisen comes from the fact that skin potentials do not drop under all conditions of low extracellular potassium. Relatively high skin potentials associ- ated with inside and outside leakage were observed when diluted saline (corre- sponding to Ringer's) was used (29). Very low potentials, on th
Electrolytes in biological systems, incorporating Electrolytes in biological systems, incorporating papers presented at a symposium at the Marine Biological Laboratory in Woods Hole, Massachusetts, on September 8, 1954 electrolytesinbi00shan Year: 1955 226 ELECTROLYTES IN BIOLOGICAL SYSTEMS has now arisen comes from the fact that skin potentials do not drop under all conditions of low extracellular potassium. Relatively high skin potentials associ- ated with inside and outside leakage were observed when diluted saline (corre- sponding to Ringer's) was used (29). Very low potentials, on the other hand, 12 10 4 - 2 - - X CONTROL FROGS • ACTH FROGS -I— 20 MILLIVOLTS Fig. 13. Dependence of K''' rejection from the epithelium on skin potential. Skins of normal frogs and frogs pretreated with a purified ACTH preparation. Rana pipiens. Calcium- free Ringer's on both sides of the skin. For treatment of frogs 3 to 5 mg of the hormone was implanted in the dorsal lymph sac and kept there for 3 days, after which the animals were killed (28). were seen in potassium-deficient solutions of physiological or higher than physiological sodium chloride levels. It is hard to understand why, then, if po- tassium should be solely subjected to electrostatic forces, some of the potassium should be released from the outside and another portion from the inside of the skin, especially since, under conditions leading to very low skin potentials (3-5 mv), the same kind of inside and outside leakage could be observed.
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