. The endocrine organs; an introduction to the study of internal secretion . ll, Cyon, Dixon and Halliburton,and Jordan and Eyster, have obtained no definite result from pineal ex-tracts so far as arterial pressure and kidney secretion are concerned; ifwe except the fall in blood-pressure, which Dixon and Halliburton considerto be non-specific. EFFECTS OF EXTIRPATION. RELATIONS OF THE PINEAL WITH THE SEXUAL GLANDS Extirpation of the pineal is a difficult operation to carry through with-out provoking severe haemorrhage, to which the animals operated on havegenerally succumbed. The most complete
. The endocrine organs; an introduction to the study of internal secretion . ll, Cyon, Dixon and Halliburton,and Jordan and Eyster, have obtained no definite result from pineal ex-tracts so far as arterial pressure and kidney secretion are concerned; ifwe except the fall in blood-pressure, which Dixon and Halliburton considerto be non-specific. EFFECTS OF EXTIRPATION. RELATIONS OF THE PINEAL WITH THE SEXUAL GLANDS Extirpation of the pineal is a difficult operation to carry through with-out provoking severe haemorrhage, to which the animals operated on havegenerally succumbed. The most complete series of experiments as yetmade are those of Foa on the domestic fowl, and those of Sarteschi on Effects of Extirpation 121 gland was young rabbits and puppies. In pullets in which the pinealdestroyed no difference could be noted on comparison with controls, but incockerels Foa describes not only a more rapid growth of the body, but anearlier development of the testicles and of the secondary sexual results obtained by Sarteschi agree generally with FIG. 85.—Effect on kidney volume and blood-pressure of intravenous injection of asolution in Ringers fluid of dried alcohol extract of sheep pineal. a, kidney volume; b, blood-pressure ; c, urine drops ; d, time in ten seconds ; e, signal. In connexion with this it is noteworthy that abnormal growth of theskeleton with sexual precocity and early development of secondary sexualcharacters have been observed in young boys affected by pineal tumour;although this is by no means true for all cases in which such tumours havebeen found. In some in which secondary sexual characters were presentthere was an unusually large amount of the interstitial tissue in thetesticles, although these organs had otherwise remained small. It is pro- 122 The Endocrine Organs
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