. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. REPORTS FROM THE MBL GENERAL SCIENTIFIC MEETINGS 359 MW CB »i- MBP 106- 80-1 50- 0 -MBP CCJ xfF 0L. antibody (Fig. 1C). Likewise, in the corresponding region of the 4 cm embryo, PO staining (Fig. 1D) was stronger and more wide- spread than that of MBP. Uyemura el al. (8) used immunoblot to show that P0 expression preceeded that of MBP in the chick sciatic nerve. Taken together, these results are in line with the possibility that the early expression of externally oriented P0 may play a role in heterophilic interactions with
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. REPORTS FROM THE MBL GENERAL SCIENTIFIC MEETINGS 359 MW CB »i- MBP 106- 80-1 50- 0 -MBP CCJ xfF 0L. antibody (Fig. 1C). Likewise, in the corresponding region of the 4 cm embryo, PO staining (Fig. 1D) was stronger and more wide- spread than that of MBP. Uyemura el al. (8) used immunoblot to show that P0 expression preceeded that of MBP in the chick sciatic nerve. Taken together, these results are in line with the possibility that the early expression of externally oriented P0 may play a role in heterophilic interactions with molecules on the surfaces of the large caliber axons about to be myelinated. In this regard that the molecule designated for this role in mam- mals, myelin-associated glycoprotein (see 9, for review), is absent from shark (10). These studies were supported by grants from the NIH (NS- 13980) and National Multiple Sclerosis Society. Literature Cited 1. Young, J. Z. 1989. The Lite of I 'ertehrates. Third Clarendon Press. 2. \\aehneldt, T. V., , Matthieu, and G. Jeserich. 1986. Neurochem. Int. 9: 463. 3. Lemke. G., and R. Axel. 1985. Cell 40: 501. 4. D'Urso, D., P. J. Brophy, S. M. Slaugaitis, C. S. Gillispie, A. B. Frey, G. Spempak, and D. R. Colman. 1990. \eitron 2: 449. 5. Filbin, M. T., F. K. Walsh, B. D. Trapp, J. A. Pizzey, and G. I. Tennekoon. 1990. Nature 55: 500. 6. Omlin, F. X., H. deF. Webster, C. F. Palkovits, and S. R. Cohen. 1982. J. Cell Bio!. 95: 242. 1. Saavedra, R. A., L. Fors, Aebersold, B. Arden, S. Horvath, J. Sand- ers, and L. Hood. 1989. ./. Mol. Evol 29: 149. 8. Uyemura, K., K. Horie, M. Suzuki, and S. Uehara. 1979. J. Neu- rochem. 32: 779. 9. Quarles, R. H., D. R. Oilman, J. L. Salzer and B. D. Trapp. 1992. In Myelin: Biology and Chemistry. R. E. Martenson. ed. CRC Press. Boca Raton. FL. 10. Zand, D., J. Hammer, R. Gould, and R. Quarles. 1991. / Neu- rochem. 57: 1076. Figure I. (.41 A homogenate of achill medulla was electrophoresed on V%
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