. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. 5o8 Malaria cox, R. Blanchard, igoo. Hsemamoeba malarias var. parva, Laveran, 1900. Plasmodium immaculatum, Schaudinn, 1902. Laverania praecox, Nocard et Leclainche, 1903. parasite of estivo-autumnal or malignant tertian malarial fever. It is a very small parasite, whose occurrence, even multiple occur- rence, in the corpuscles does not change their size or shape. It does, however, quickly change the appearance of the corpuscles, which become polychromat
. A text-book upon the pathogenic Bacteria and Protozoa for students of medicine and physicians. Bacteriology; Pathogenic bacteria; Protozoa. 5o8 Malaria cox, R. Blanchard, igoo. Hsemamoeba malarias var. parva, Laveran, 1900. Plasmodium immaculatum, Schaudinn, 1902. Laverania praecox, Nocard et Leclainche, 1903. parasite of estivo-autumnal or malignant tertian malarial fever. It is a very small parasite, whose occurrence, even multiple occur- rence, in the corpuscles does not change their size or shape. It does, however, quickly change the appearance of the corpuscles, which become polychromatophilic, and frequently show numerous small dots—the granulations of Schiiffner—in the corpuscular substance. The first appearance of the schizont is in the form of tiny rings, which appear to lie upon rather than in the corpuscles, and are first seen at the edges. The rings are outlined by extremely fine lines. Fig. 185. Fig. 186. Figs. i8s, 186.—Gametocytes of Plasmodium vivax: 87, The microgametocyte; 88, the macrogametocyte (KoUe and Wassermann). and sometimes seem to be incompletely closed, so that they are like horseshoes rather than circles. They increase to several times the original size without losing the ring shape, and are variously known as "middle-sized rings" and "large ; They are with diflSculty differentiated from the " tiny rings " of the tertian parasite. As the "large ring" stage is reached the parasites begin to disappear from the peripheral blood to complete their growth and undergo meroblast formation in the capillaries of the spleen, the brain, and the bone-marrow. Here the full-grown parasites—meroblasts— appear as irregular disks, resembling those of the quartan parasite, but smaller in size. The pigment is gathered toward the center in a little niass, and eight to twenty-five merozoits are formed in a morula' or mulberry-like mass similar to those of the tertian para- site.* Two or three parasite
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