. Calcified tissues; proceedings. Bone; Collagen; Calcification. Intestinal Absorption and Skeletal Dynamic of Calcium in Acromegaly 257 in normal subjects (Blau et uL, 1954; Bronner et al., 1956, 1963; de Grazia and Rich, 1964). In view of these results, de Grazia and Rich (1964) maintained that the percentage of absorption may be an individual biological constant. However, the absolute rate of intestinal absorption of calcium may have a greater physiological sig- nificance. Bronner et al. (1963) have shown that in normal and osteoporotic subjects, the amount of calcium absorbed and the bone
. Calcified tissues; proceedings. Bone; Collagen; Calcification. Intestinal Absorption and Skeletal Dynamic of Calcium in Acromegaly 257 in normal subjects (Blau et uL, 1954; Bronner et al., 1956, 1963; de Grazia and Rich, 1964). In view of these results, de Grazia and Rich (1964) maintained that the percentage of absorption may be an individual biological constant. However, the absolute rate of intestinal absorption of calcium may have a greater physiological sig- nificance. Bronner et al. (1963) have shown that in normal and osteoporotic subjects, the amount of calcium absorbed and the bone formation rate are linked by a linear relationship. The results of Bronner indicate also that a linear relation exists between the two bone remodelling processes and that bone formation increases more rapidly than bone resorption. Therefore, the balance appears to be a direct function of the intensity of bone formation, since it represents the difference between the two /OOO 2000 3000 VOOO Bone formation mg/day jiationship between bone formation and bone resorption in acromega data obtained by ! In normal and osteoporotic suj compared with the Fig. 3 shows the relationship between bone formation and bone resorption in four acromegalic patients and in normals as reported by Bronner et al. (1963). A linear relationship seems to exist in acromegalic patients between the two parameters. However, in spite of the high rate of bone formation, calcium balance in these patients is never as positive as might have been predicted by the relationship between bone formation and bone resorption found to prevail in normal subjects. Also the intestinal absorption of calcium seems to be directly correlated with bone accretion rate as shown in Fig. 4. However calcium absorption, although normal or even increased, never reaches the values which would be expected on the basis of bone formation rate. If calcium homeostasis implies that the calcium pool is constant, losses and ent
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