Studies from the laboratories of the Deptof Surgery . ceof the shaft, frequently occurred (Figs. 11 to 17). This .sequestrumwas separated from a newly formed involucrum bv a zone of debrisand leukocytes; therefore, all the factors of an acute osteomvelitis werepresent with the exception probably of bacteria and their showed the sequestrum with an involucrum >urroun(ling it butseparated from it by a zone of pus. The cortical lione of sequestrumshowed absence of nuclei, and throughout its cancellous portion there 28 was a marked inhltration of leukocytes. The invulucruni
Studies from the laboratories of the Deptof Surgery . ceof the shaft, frequently occurred (Figs. 11 to 17). This .sequestrumwas separated from a newly formed involucrum bv a zone of debrisand leukocytes; therefore, all the factors of an acute osteomvelitis werepresent with the exception probably of bacteria and their showed the sequestrum with an involucrum >urroun(ling it butseparated from it by a zone of pus. The cortical lione of sequestrumshowed absence of nuclei, and throughout its cancellous portion there 28 was a marked inhltration of leukocytes. The invulucruni consisted ofnewly formed subperiosteal bone. In the prolonged animal experiments roentgenologic studies showedthe gradual disappearance of the sequestrum so that at the end of twomonths it was impossible to detect its former outlines by the roentgenrav (Figs. IS to 22). Microscopic sections taken at this time showedthe disappearance of the zone of separation; and the former seques-tnmi was then united to the living hone by blood vessels entering the. Fig. 27 (Case 2).—Roentgenogram taken, Feb. 7, 1920; operation, , 1919; anterior surface of the cortex of the tibia removed; drainage tube inpopliteal space shown. haversian canals. The prf)cess was similar to that found in any bonetransplant, gradual absorption and deposition of new bone occurringthroughout the haversian canals until all the dearl bone had beenreplaced. I have emphasized these facts because I believe they have a definiteinfluence on human surgery. I shall show in the study of clinical casesthat in children bone tissues that are ajjiiarently dearl can be saved, toadvantage. 29 Since the introduction of the Carrel-Uakin technic, we have hadresults on Dr. Pools service at the New York Hospital which corre-spond to a certain degree wnth results found in our experimental following two cases show marked regeneration of 1x>ne which oneither roentgen-ray or gross examination appeared necrotic.
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