Transactions of the Royal Society of Edinburgh . Fig. 49a.—Secretion of bile before and after potassium sulphate. 1\ and 35 cc. water injected into duodenum at b, the same with 142grains potassium sulphate injected at s, and again at *. Necropsy.—Small intestine contained 143 cc. watery fluid. The vascularityof the mucous membrane in the whole length of the small intestine was slightlyincreased. There being in this case evidence of a slight increase of the biliary secretion,another experiment was thought desirable. 200 PROFESSOR RUTHERFORD ON THE Experiment 49b. Dog that had fasted sev


Transactions of the Royal Society of Edinburgh . Fig. 49a.—Secretion of bile before and after potassium sulphate. 1\ and 35 cc. water injected into duodenum at b, the same with 142grains potassium sulphate injected at s, and again at *. Necropsy.—Small intestine contained 143 cc. watery fluid. The vascularityof the mucous membrane in the whole length of the small intestine was slightlyincreased. There being in this case evidence of a slight increase of the biliary secretion,another experiment was thought desirable. 200 PROFESSOR RUTHERFORD ON THE Experiment 49b. Dog that had fasted seventeen hours. Weight 21*5 kilo-grammes (fig. 49b).—232 grains potassium sulphate dissolved in 32 cc. waterat 37° C. and injected into duodenum at Fig. 49b.—Secretion of bile before and after 232 grains potassium sulphatedissolved in 32 cc. water at 37° C, and injected into duodenum at^?. Experiment 49b. Secretion Secretion of bile per of bile per kilogramme 15. of dog: per hour. cc. 1 80 1 90 1 70 ^ 11 6565 V 0-316 cc. 1 70 ) P —1 80 1 70 1 90 1 80 1 90 2 05 2 07 2 10 2 25 2 37 2 45 2 40 2 45 2 50 2 47 2 55 ^ 22 55 57 V047cc. 2 45 J 2 40 2 30 2 40 2 40 ^ 2 1 2095 V 0-352 cc. 1-20 ) Necropsy.—Increased vascularity of mucous membrane in whole length ofsmall intestine. The small intestine contained 90 cc. clear brownish fluid,with numerous mucous flakes. There was, therefore, evidence of considerablepurgative action. Results of Experiments with Potassium Sulphate.—Experiment 49b showsthat potassium sulphate is undoubtedly a hepatic stimulant. The dose of 232grains, given in this case to a full-sized dog, was just the maximum dose for aman. The negative effect of 124 grains in Experiment 49, and the slight effectof 142 gra


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