. Biophysical science. Biophysics. 100 3 50 r 110 mv 0L 2 msec. Figure II. Predicted and observed action potential, (a) shows the curve predicted by equations developed in this section, whereas (b) is a tracing of an actual action potential observed on an axon. After A. L. Hodgkin and A. F. Huxley, "A Quantitative Description of Membrane Current and its Application to Conduction and Excitation in Nerve," J. Physiol. 117: 500 (1952). experiments and the significance of the minimum of six rate constants found. 5. Summary The equations and experiments of Hodgkin and Huxley have been che
. Biophysical science. Biophysics. 100 3 50 r 110 mv 0L 2 msec. Figure II. Predicted and observed action potential, (a) shows the curve predicted by equations developed in this section, whereas (b) is a tracing of an actual action potential observed on an axon. After A. L. Hodgkin and A. F. Huxley, "A Quantitative Description of Membrane Current and its Application to Conduction and Excitation in Nerve," J. Physiol. 117: 500 (1952). experiments and the significance of the minimum of six rate constants found. 5. Summary The equations and experiments of Hodgkin and Huxley have been checked by other investigators and found essentially correct. These equations rule out all previous molecular models and they rule out passive diffusion of Na+ ions. However, the equations cannot supply any model related to known molecules. One could fit the acetylcholine activity into these equations by per- mitting ACh to react with a variety of molecules in the membrane having a variety of effects. To do this, one has to produce a mysterious (that is, unknown) mechanism for releasing an amount of ACh which is a complex function of the membrane potential. Although Nachman- sohn's conclusions, that is, ACh and cholinesterase are necessary for the conduction of spike potentials in axons, appear quite justified, the work of Hodgkin and Huxley makes it clear that these can be but two of a number of molecules necessary to explain the action of the neuron Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ackerman, Eugene, 1920-. Englewood Cliffs, N. J. , Prentice-Hall
Size: 2868px × 871px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookcollectionbiodiversi, booksubjectbiophysics
