. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. 74 Discussion through it or put a vacuum on so that you get the gas out, you break the structure down. Gray: If you remove the oxygen chemically then they are protected ? Hollaender: Yes. In the curve shown in Fig. 1 the change in viscosity with increasing irradiation was seen. Now if AET is added (Fig. 2), no effect on viscosity is observed without irradiation (upper curve). With 250 r a very large decrease is observed without the AET
. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. 74 Discussion through it or put a vacuum on so that you get the gas out, you break the structure down. Gray: If you remove the oxygen chemically then they are protected ? Hollaender: Yes. In the curve shown in Fig. 1 the change in viscosity with increasing irradiation was seen. Now if AET is added (Fig. 2), no effect on viscosity is observed without irradiation (upper curve). With 250 r a very large decrease is observed without the AET (middle curve), but with small concentrations a large protective effect is seen. With 900 r (lower curve) more AET is needed for maximal protection. Much more complete protection is observed with lower doses of CONCN. OF AET (mmoles/liter) Fig. 2. (Hollaender). Protective effect of *S'-j3-amino- ethyh'sothiouronium bromide HBr on crude rat thymus preparation (W. Fisher, unpublished). There is, however, a viscosity change which AET will not protect against. de Hevesy: Dr. Lajtha mentioned the effect of the irradiation of the spleen. Is this effect not due to an interference with the formation of a humoral substance and is the much greater effectiveness of the whole- body radiation not partly due to the supression of the formation of this substance in the whole organism? Alexander: With regard to the irradiation of DNA in vitro, the resist- ance of DNA to radiation, which has been stressed by Butler, is more apparent than real. Dr. K. A. Stacey (1955, Int. Conf. TtadiohioL, Cambridge, 1954, report, 32, 29) at our Institute irradiated DNA from herring sperm in the dry state and then measured its mole- cular weight by light scattering. From the change in molecular weight the energy needed to break one polynucleotide bond can be Please note that these images are extracted from scanned page images that may have been digitally enhanced for readabilit
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