. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 168 G. U. THORINGTON AND D. A. HESSINGER E LU o O LL LU > (/) LU I Q <. log SENSITIZER, M Figure 1. Dose-response curves of the cnidocyte response to glycine and N-acetylneuraminic acid (NANA). The dose-response curves for glycine (dashed line; mean n = 49, ranging from 31 to 72) and NANA (solid line; mean n = 90, ranging from 53 to 150) are typical of two types of chemosensitizing agents. Results are expressed as means of adhesive force (mgf) after correcting for adhesion with seawater alone, with vertical bars repres
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 168 G. U. THORINGTON AND D. A. HESSINGER E LU o O LL LU > (/) LU I Q <. log SENSITIZER, M Figure 1. Dose-response curves of the cnidocyte response to glycine and N-acetylneuraminic acid (NANA). The dose-response curves for glycine (dashed line; mean n = 49, ranging from 31 to 72) and NANA (solid line; mean n = 90, ranging from 53 to 150) are typical of two types of chemosensitizing agents. Results are expressed as means of adhesive force (mgf) after correcting for adhesion with seawater alone, with vertical bars representing standard errors of means (95% confi- dence limits). Dixon-type plots (Dixon, 1953) of the reciprocal of ad- hesive force versus inhibitor concentration yield straight lines for different concentrations of amino agonists (Fig. 3). These lines intersect at a common point that is indica- tive of competitive inhibition (Segel, 1976) and which gives the K, for the antagonist. Discussion Results of our qualitative survey of more than 60 bio- chemicals for the ability to chemosensitize A pallida cni- docytes confirm and extend the observations of Lubbock (1979) who used the large anemone Stichodactyla had- doni. Lubbock, using glass rods to present simulta- neously the tactile stimulus and the chemical stimulus, showed that mucin and a few proteins—among 32 tested substances—allowed strong responses, while polysac- charides and lipids were virtually inactive. In the present survey we found that mucins, and specifically glycopro- teins and a mucopolysaccharide, chemosensitize cnido- cytes. In addition, however, we found that a wide variety of amino compounds and certain sugars strongly sensi- tize cnidocytes in the tentacles of A. pallida. Further- more, A. pallida responded much more strongly to hya- luronic acid and polylysine and much less to a-casein than did S. haddoni. The present study demonstrates that cnidocyte che- mosensitization occurs either with the sensitizers
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