AMAarchives of neurology & psychiatry . will be seen, failed to save therest of the brain from damage. Separated, at times even remotely, from tliC main tumor mass werenumerous microsco])ic feci of cancer cells (Fig. 7). Such foci con-sisted of a small blood \essel, infiltrated or occluded by large tumorcells, with nuclei very rich in chromatin and provided with a welldeveloped membrane. Sometimes the cells were confined to the Xirchow- HASSIX-SIXGER—CEREBRAL CARCIXOMA 165 Robin spaces, but often tbey had broken through and, by proliferation,formed a larger focus. Then no trace of blood vessel
AMAarchives of neurology & psychiatry . will be seen, failed to save therest of the brain from damage. Separated, at times even remotely, from tliC main tumor mass werenumerous microsco])ic feci of cancer cells (Fig. 7). Such foci con-sisted of a small blood \essel, infiltrated or occluded by large tumorcells, with nuclei very rich in chromatin and provided with a welldeveloped membrane. Sometimes the cells were confined to the Xirchow- HASSIX-SIXGER—CEREBRAL CARCIXOMA 165 Robin spaces, but often tbey had broken through and, by proliferation,formed a larger focus. Then no trace of blood vessel could be detected,and the reactive and other phenomena approximated those of the maingrowth already described. Regions Remote Ereu from Microscopic Foci.—These regionsat first glance appeared normal. Closer study revealed universalpathologic changes. The ganglion cells were often swollen, withchromatolysis, eccentric nucleus, neuronophagia and fat infiltration. Theglia cells were hypertrophied (cytoplasmic) or proliferated in the. Fig. 9.—Necrotic areas with islands of carcinoma. The small area A showsa colorless center, devoid of vessels, surrounded by a zone containing a fewdegenerated cancer cells and an outer dense ring of well preserved cancer blue : X 36. form of rosettes. The vessels were dilated, and there were manvnew formed capillaries. Some vessels were surrounded by a ring ofsyncytial cytoplasmic glial cells (Fig. 8). Masses of pigment granuleswere contained within the proliferated adventitial and endothelial nerve fibers in places appeared swollen and spindle-shaped but notfragmented. In short, there was a generalized condition of toxicencephalitis. 166 AKCHIIES or StLLROLOCV AS I) ISYC II LIT RV ( )f the torei^foing changes those most constant were: general toxicencephalitis, the colloid masses and the ])rocesses in the transition most of the cases the demarcation zone, as stated, was absent, andinvasion of the ganglions by
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