. On the Action of Cobra Venom. Parts I and II. Fia. 9.—Action of venom (1 : 100,000) on surviving intestine of rabbit in Eingers solution. amounts of the poison are employed. In experiments on the gut of the rabbit andcat, carried out in the same way as mine, Gunn observed only a depressor action andarrest of the movements. But he seems to have generally used very much higherconcentrations than I found necessary, such as 1: 10,000-25,000. In one tracing. Fig. 10.—Action of venom (1 : 20,000) on surviving intestine of rabbit in Eingers solution. given by him of the effect of 1 in 10,000, the e
. On the Action of Cobra Venom. Parts I and II. Fia. 9.—Action of venom (1 : 100,000) on surviving intestine of rabbit in Eingers solution. amounts of the poison are employed. In experiments on the gut of the rabbit andcat, carried out in the same way as mine, Gunn observed only a depressor action andarrest of the movements. But he seems to have generally used very much higherconcentrations than I found necessary, such as 1: 10,000-25,000. In one tracing. Fig. 10.—Action of venom (1 : 20,000) on surviving intestine of rabbit in Eingers solution. given by him of the effect of 1 in 10,000, the effect may have been inhibition, as hesupposes, or depression such as I have observed; but in another tracing, in which heused 1 in 60,000, the change is clearly a slow depressant one, and quite different fromthe inhibition which is observed under adrenaline. I cannot agree that cobra venomexercises any inhibitory action on the intestine comparable to that of adrenaline. Itscharacteristic action is a primary stimulation, best seen in low coacentrations, and a ON THE ACTION OF COBRA VEKOM. 33 secondary paralysis when higher concentrations are used ; when strong solutions areapplied to the isolated intestine this depressor action may occur alone. 10. The Uterus. Experiments were performed on the isolated uterus suspended in oxygenatedRinger s solution in the usual way. As was found by Gunn, cobra venom produces contraction of the isolated uterus of
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