. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. THE EFFECT OF CYANIDES ON PROTOPLASM. 321 /COO JOO gOO 700 555 JOO 10O 300 * N N _N_ M H JH_ foe goo ^oo too foo too vo. _ N_ N_ _N_ _N_ _y_ M JH_ _J1_ /OOO «X) 800 7E» 600 760 WO 30O FIG. 6. All the velocity constants plotted against their respective concentra- tions to show that the velocity constants increase at a regular rate with increase in concentration of HCN and increase in time of exposure to these concentrations. DISCUSSION. Lillie's ('13) explanation of the phenomenon of antagonism by various anaesthetics an
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. THE EFFECT OF CYANIDES ON PROTOPLASM. 321 /COO JOO gOO 700 555 JOO 10O 300 * N N _N_ M H JH_ foe goo ^oo too foo too vo. _ N_ N_ _N_ _N_ _y_ M JH_ _J1_ /OOO «X) 800 7E» 600 760 WO 30O FIG. 6. All the velocity constants plotted against their respective concentra- tions to show that the velocity constants increase at a regular rate with increase in concentration of HCN and increase in time of exposure to these concentrations. DISCUSSION. Lillie's ('13) explanation of the phenomenon of antagonism by various anaesthetics and of anaesthesia in general is based on his experiments which showed that in every case the anaesthetics which he used prevented a general increase in permeability brought about by various salts which are toxic to the cell. That this decrease in permeability by anaesthetics does not always follow, at least when HCN is used as an anaesthetic, is shown by the preceding experiments. Heilbrunn ('25) has also found that ether in various concentrations increases the permeability of Arbacia eggs to water. The difference in the results obtained by Lillie and those reported in this paper may possibly be due to the difference in types of anaesthetics used. HCN, as is very well known, dissociates only very slightly. That it enters the cell as a molecule, as does CO2 Qjacobs ('23')^ and H2S [^Beerman ('24)], has been shown by Bodine ('24). Bodine suggests that HCN enters the cell as a molecule and ionizes within the cell to give an intracellular acidity even though the extra-cellular HCN solution is slightly Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1
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