Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . very slightest detectable change in thecolour towards the acid side, probably due to thesmall amount of urine secreted before the respiratorycentre had brought the reaction of the blood tonormal. We know from Lawrence Hendersons work(1913) that the rise in hydrogen-ion concentrationof bicarbonate solutions when partially neutralisedwith acid is not great because the carbon dioxideescapes. In order to obtain some idea of what therise might amount to i
Intravenous injection in wound shock : being the Oliver-Sharpey lectures delivered before the Royal College of Physicians of London in May 1918 . very slightest detectable change in thecolour towards the acid side, probably due to thesmall amount of urine secreted before the respiratorycentre had brought the reaction of the blood tonormal. We know from Lawrence Hendersons work(1913) that the rise in hydrogen-ion concentrationof bicarbonate solutions when partially neutralisedwith acid is not great because the carbon dioxideescapes. In order to obtain some idea of what therise might amount to in the blood if the respiratorycentre were less excitable than normal, owing tomorphine or other influence, so that compensationby removal of more carbon dioxide than normaldid not take place, I compared the hydrogen-ionconcentration of bicarbonate solutions of the sameconcentration as in blood, and also of blood plasmaitself, before and after neutralisation of one-half oftheir bicarbonate content by acid. When broughtinto equilibrium with alveolar air and the tints ofneutral red compared, it was obvious that those 46 INTRAVENOUS INJECTION. Fig. 14. —Effect of Muscle Injury and Haemorrhage on Respiration. Upper curve—respiration. Lower curve—blood pressure. Bottom line—time in ten second intervals. At a, muscles hammered. Rapid, shallow Blood removed. Exaggeration of respiratory effect. But later, at c,becomes slow and shallow. Injection of gum-saline at d restores the blood pressure and the respiration. IN WOUND SHOCK 47 solutions with less bicarbonate were distinctly moreacid ; the tint was crimson, instead of red. Com-paring them with standard phosphate solutions,the hydrogen-ion exponent was found to be, inSorensens nomenclature, 6*8 and 6*9 respectively,or, 1*58 xlO-7 and 1*26 xlO7 normal. We maynote that the addition of OOl gram only oflactic acid to 10,000 litres of an acid of 1*26 x 10~7would raise the hydrogen-ion to 1*58 x 10 7. I next took the m
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Keywords: ., bo, bookcentury1900, bookdecade1910, booksubjectwoundsandinjuries
