. The British journal of dermatology . d inthe f seces (mgrrm). Total iiuantityof eliminatedHg, Imgrm.). 005 010 0-05 010 0-08 0-19 012 0-29 0-14 0-42 013 0-34 0-23 0-59 0-21 063 0-17 0-47 014 0-47 013 0-51 -4- 0-51 0-08 0-70 005 0-63 003 0-75 0-03 0-70 0-12 093 1-76 ClECTJLATION OF MeRCUEY. Injected quantity of Hg. .... Eliminated by kidneys and intestine Hg. found in the viscera,, ,, ,, muscles,, ,, „ rest of the body 8-33 :Mi,rm. 15400 8-33 1-55 116-2 n-9 137-98 Quantity of mercury lost under the experiment 16 mgrm., or about11 per cent. These results show also a very slow, but in this case
. The British journal of dermatology . d inthe f seces (mgrrm). Total iiuantityof eliminatedHg, Imgrm.). 005 010 0-05 010 0-08 0-19 012 0-29 0-14 0-42 013 0-34 0-23 0-59 0-21 063 0-17 0-47 014 0-47 013 0-51 -4- 0-51 0-08 0-70 005 0-63 003 0-75 0-03 0-70 0-12 093 1-76 ClECTJLATION OF MeRCUEY. Injected quantity of Hg. .... Eliminated by kidneys and intestine Hg. found in the viscera,, ,, ,, muscles,, ,, „ rest of the body 8-33 :Mi,rm. 15400 8-33 1-55 116-2 n-9 137-98 Quantity of mercury lost under the experiment 16 mgrm., or about11 per cent. These results show also a very slow, but in this casemore or less regular absorption. Theeapedtic Conclusions. It has been discussed widely whether mercury in the infected bodyacts directly upon the spirochastes or more indirectly on the humanorganism by stimulating the bactericidal forces in it. Of thesetheories the latter is to be preferred in my opinion. Eighteenexaminations of blood from patients under full mercury treatment or ABS(^RPTION AND ELIMINATION OF MERCUKY. 371 Tahle For explanation of figxires see Table I. p. 356. 372 ABSORPTION AND ELIMINATION OF MERCURY. severely intoxicated with this metal have shown me that the averagecontent of mercury amounts to 1-2 mgrm. only per litre and neverexceeds 3 mgrm. This concentration is so feeble that it makes adirect bactericidal effect very improbable. Moreover I found, as theresult of .some investigation made in collaboration with Dr. A. Kiss-meyer, that a colony of spirochtetes grew well in horse-serumcontaining 5-10 mgrm. HgCl2 per litre and still distinctly in serumcontaining 20 mgrm. per litre. Under these circumstances the aim ofthe ti-eatment must be to avoid all intoxications in order to avoiddamage to the body and its bactericidal forces, but at the same timeto maintain a sufficiently high permanent concentration of mercury inthe organism without risking aii intoxication. One has to remember that during administration the slow elimina-tion allows an increasing a
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Keywords: ., bookcentury1800, bookdecade1880, booksubjectsyphilis, bookyear188
